No products in the cart.
Rabbit Polyclonal Phospho-HDAC4 (S632) antibody (STJ90285)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for HDAC4 (phospho Ser632) Polyclonal Antibody.
Check alternative names for the antibodyExpand
HDAC4 antibody, KIAA0288 antibody,|AHO3 antibody|MEF2-interacting transcription repressor MITR antibody|MITR antibody|NY-CO-9 antibody|Anti-HDAC4 antibody (ab12172)
SCBT cat No: sc-46672|sc-365093|sc-48390|sc-365367|sc-11418|sc-56686|sc-5246|sc-5245|sc-11421|
HDAC4 (phospho Ser632) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-HDAC4 (S632) Polyclonal Antibody detects endogenous levels of HDAC4 protein only when phosphorylated at S632.
Synthesized phospho-peptide derived from HDAC4 (phospho Ser632) at AA range 570-650
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:20000;
|Molecular weight|| |
HDAC4 (phospho Ser632) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
HDAC4 (phospho Ser632) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Histone deacetylase 4 antibody, HD4 antibody,
|Protein names|| |
Histone deacetylase 4 , HD4 ,
|Protein function|| |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. / Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
|Protein tissue specificity|| |
|Involvement in disease|| |
Brachydactyly-mental retardation syndrome (BDMR) [MIM:600430]: A syndrome resembling the physical anomalies found in Albright hereditary osteodystrophy. Common features are mild facial dysmorphism, congenital heart defects, distinct brachydactyly type E, mental retardation, developmental delay, seizures, autism spectrum disorder, and stocky build. Soft tissue ossification is absent, and there are no abnormalities in parathyroid hormone or calcium metabolism. . Note: The gene represented in this entry is involved in disease pathogenesis. HDAC4 point mutations and chromosomal microdeletions encompassing this gene have been found in BDMR patients (PubMed:20691407, PubMed:24715439, PubMed:23188045). However, HDAC4 haploinsufficiency is not fully penetrant and multiple genes may contribute to manifestation of the full phenotypic spectrum (PubMed:24715439, PubMed:23188045). .
|Protein sequence and domain|| |
The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm. / Belongs to the histone deacetylase family. HD type 2 subfamily.
|Protein post-translational modifications|| |
Phosphorylated by CaMK4 at Ser-246, Ser-467 and Ser-632. Phosphorylation at other residues by CaMK2D is required for the interaction with 14-3-3. Phosphorylation at Ser-350 impairs the binding of ANKRA2 but generates a high-affinity docking site for 14-3-3. / Sumoylation on Lys-559 is promoted by the E3 SUMO-protein ligase RANBP2, and prevented by phosphorylation by CaMK4.
|Protein cellular localization|| |
Nucleus / Cytoplasm
AntibodyPlus can customize HDAC4 (phospho Ser632) Antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.
St John’s Laboratory Ltd.
|Product type|| |
There are no reviews for this product yet.
By submitting a review, get following benefits:
1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!
There is no extra validation for this product yet.
Check other extra validated antibodies below: