Rabbit Polyclonal Phospho-HDAC5 (S498) antibody (STJ90286)

$99.00$319.00

Reactivity: Human, Mouse
Applications: WB, IHC, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-HDAC5 (S498) antibody (STJ90286)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for HDAC5 (phospho Ser498) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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HDAC5 antibody, KIAA0600 antibody,|Antigen NY CO 9 antibody|Antigen NY-CO-9 antibody|HD5 antibody|HDAC 5 antibody|HDAC5 antibody|HDAC5_HUMAN antibody|Histone deacetylase 5 antibody|NY CO 9 antibody|Anti-HDAC5 antibody (ab1439)
SCBT cat No: sc-133106|sc-133225|sc-5250|sc-11419|sc-5252|sc-28386|

 

Name

HDAC5 (phospho Ser498) Polyclonal Antibody

Catalogue No.

STJ90286

Reactivity

Human, Mouse

Specificity

Phospho-HDAC5 (S498) Polyclonal Antibody detects endogenous levels of HDAC5 protein only when phosphorylated at S498.

Immunogen

Synthesized phospho-peptide derived from HDAC5 (phospho Ser498) at AA range 440-520

Host

Rabbit

Applications

WB, IHC, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

122 kDa

Formulation

HDAC5 (phospho Ser498) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

HDAC5 (phospho Ser498) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Histone deacetylase 5 antibody, HD5 antibody, Antigen NY-CO-9 antibody

Database links

Human UniProt/Swiss-Prot:Q9UQL6;Human Entrez Gene: 10014;Mouse Entrez Gene: 15184;Rat Entrez Gene: Rn.79863

Protein names

Histone deacetylase 5 , HD5 , Antigen NY-CO-9

Protein function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. / Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Protein tissue specificity

Ubiquitous.

Protein sequence and domain

The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm. / Belongs to the histone deacetylase family. HD type 2 subfamily.

Protein post-translational modifications

Phosphorylated by AMPK, CaMK1, SIK1 and PRKD1 at Ser-259 and Ser-498. The phosphorylation is required for the export to the cytoplasm and inhibition. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Phosphorylated by GRK5, leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription (By similarity). / Ubiquitinated. Polyubiquitination however does not lead to its degradation.

Protein cellular localization

Nucleus / Cytoplasm

Research area

All research areas>Transcription Regulators>HDAC
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize HDAC5 (phospho Ser498) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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