Rabbit Polyclonal Phospho-HDAC6 (S22) antibody (STJ91082)

$99.00$319.00

Reactivity: Human, Mouse
Applications: WB, IHC, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit Polyclonal Phospho-HDAC6 (S22) antibody (STJ91082)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for HDAC6 (phospho Ser22) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

Expand

HDAC6 antibody, KIAA0901 antibody, JM21 antibody,|CPBHM antibody|FLJ16239 antibody|HD 6 antibody|HD6 antibody|HDAC 6 antibody|HDAC6 antibody|HDAC6_HUMAN antibody|Histone deacetylase 6 (HD6) antibody|Histone deacetylase 6 antibody|JM 21 antibody|JM21 antibody|KIAA0901 antibody|OTTHUMP00000032398 antibody|OTTHUMP00000197663 antibody|PPP1R90 antibody|Protein phosphatase 1 regulatory subunit 90 antibody|Anti-HDAC6 antibody (ab1440)
SCBT cat No: sc-28386|sc-11420|sc-5258|sc-5255|

 

Name

HDAC6 (phospho Ser22) Polyclonal Antibody

Catalogue No.

STJ91082

Reactivity

Human, Mouse

Specificity

Phospho-HDAC6 (S22) Polyclonal Antibody detects endogenous levels of HDAC6 protein only when phosphorylated at S22.

Immunogen

Synthesized phospho-peptide derived from HDAC6 (phospho Ser22) at AA range 1-80

Host

Rabbit

Applications

WB, IHC, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

131 kDa

Formulation

HDAC6 (phospho Ser22) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

HDAC6 (phospho Ser22) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Histone deacetylase 6 antibody, HD6 antibody,

Database links

Human UniProt/Swiss-Prot:Q9UBN7;Mouse UniPort/Swiss-Prot: Q9Z2V5;Rat UniProt/Swiss-Port: A0A0G2QC41;Human Entrez Gene: 10013;Mouse Entrez Gene: 15185;Rat Entrez Gene: Rn.13453

Protein names

Histone deacetylase 6 , HD6 ,

Protein function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. / In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy. / Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. / Zn2+

Involvement in disease

Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia (CDP-PBHM) [MIM:300863]: A disease characterized by chondrodysplasia, severe platyspondyly, hydrocephaly, and facial features with microphthalmia. Bone abnormalities include a distinctive metaphyseal cupping of the metacarpals, metatarsals, and phalanges. Affected females show a milder phenotype with small stature, sometimes associated with body asymmetry and mild mental retardation. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the histone deacetylase family. HD type 2 subfamily. / Contains 1 UBP-type zinc finger.

Protein post-translational modifications

Phosphorylated by AURKA. / Ubiquitinated. Its polyubiquitination however does not lead to its degradation. / Sumoylated in vitro.

Protein cellular localization

Nucleus / Cytoplasm / Perikaryon / Cell projection > dendrite / Cell projection > axon

Research area

All research areas>Transcription Regulators>HDAC
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize HDAC6 (phospho Ser22) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!