No products in the cart.
Rabbit Polyclonal Phospho-HDAC6 (S22) antibody (STJ91082)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for HDAC6 (phospho Ser22) Polyclonal Antibody.
Check alternative names for the antibodyExpand
HDAC6 antibody, KIAA0901 antibody, JM21 antibody,|CPBHM antibody|FLJ16239 antibody|HD 6 antibody|HD6 antibody|HDAC 6 antibody|HDAC6 antibody|HDAC6_HUMAN antibody|Histone deacetylase 6 (HD6) antibody|Histone deacetylase 6 antibody|JM 21 antibody|JM21 antibody|KIAA0901 antibody|OTTHUMP00000032398 antibody|OTTHUMP00000197663 antibody|PPP1R90 antibody|Protein phosphatase 1 regulatory subunit 90 antibody|Anti-HDAC6 antibody (ab1440)
SCBT cat No: sc-28386|sc-11420|sc-5258|sc-5255|
HDAC6 (phospho Ser22) Polyclonal Antibody
|Catalogue No.|| |
Phospho-HDAC6 (S22) Polyclonal Antibody detects endogenous levels of HDAC6 protein only when phosphorylated at S22.
Synthesized phospho-peptide derived from HDAC6 (phospho Ser22) at AA range 1-80
WB, IHC, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000;
|Molecular weight|| |
HDAC6 (phospho Ser22) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
HDAC6 (phospho Ser22) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Histone deacetylase 6 antibody, HD6 antibody,
|Protein names|| |
Histone deacetylase 6 , HD6 ,
|Protein function|| |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. / In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy. / Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. / Zn2+
|Involvement in disease|| |
Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia (CDP-PBHM) [MIM:300863]: A disease characterized by chondrodysplasia, severe platyspondyly, hydrocephaly, and facial features with microphthalmia. Bone abnormalities include a distinctive metaphyseal cupping of the metacarpals, metatarsals, and phalanges. Affected females show a milder phenotype with small stature, sometimes associated with body asymmetry and mild mental retardation. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the histone deacetylase family. HD type 2 subfamily. / Contains 1 UBP-type zinc finger.
|Protein post-translational modifications|| |
Phosphorylated by AURKA. / Ubiquitinated. Its polyubiquitination however does not lead to its degradation. / Sumoylated in vitro.
|Protein cellular localization|| |
Nucleus / Cytoplasm / Perikaryon / Cell projection > dendrite / Cell projection > axon
AntibodyPlus can customize HDAC6 (phospho Ser22) Antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.
St John’s Laboratory Ltd.
|Product type|| |
There are no reviews for this product yet.
By submitting a review, get following benefits:
1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!
There is no extra validation for this product yet.
Check other extra validated antibodies below: