Rabbit Polyclonal Phospho-HDAC8-S39 antibody (AP0360)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-HDAC8-S39 antibody (AP0360)

Supplier: ABclonal Inc.

Recommended applications: IHC,IF

Recommended dilution:

IHC 1:50 – 1:100
IF 1:100 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit Polyclonal Phospho-HDAC8-S39 antibody.

Alternative names:

Check alternative names for the antibody

Expand

HD8 antibody; WTS antibody; RPD3 antibody; CDA07 antibody; CDLS5 antibody; MRXS6 antibody; HDACL1 antibody;
CDA07 antibody|CDLS5 antibody|HD 8 antibody|HD8 antibody|HDAC 8 antibody|Hdac8 antibody|HDAC8_HUMAN antibody|HDACL 1 antibody|HDACL1 antibody|Histone deacetylase 8 antibody|Histone deacetylase like 1 antibody|MRXS6 antibody|RPD 3 antibody|RPD3 antibody|WTS antibody|Anti-HDAC8 antibody [EPR10338(2)] (ab187139)

SCBT cat No: sc-365620|sc-17778|sc-374180|sc-11405|sc-56687|sc-11544|sc-398003|

Name

Rabbit Polyclonal Phospho-HDAC8-S39 antibody

Catalogue No.

AP0360

Reactivity

Human, Mouse, Rat

Immunogen

A phospho specific peptide corresponding to residues surrounding S39 of human HDAC8

Host

Rabbit

Applications

IHC, IF

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

42kDa

Formulation

Phospho-HDAC8-S39 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HD8 antibody; WTS antibody; RPD3 antibody; CDA07 antibody; CDLS5 antibody; MRXS6 antibody; HDACL1 antibody;

Protein names

HD8; WTS; RPD3; CDA07; CDLS5; MRXS6; HDACL1;

Protein function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.

Protein tissue specificity

Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney.

Protein sequence and domain

Belongs to the histone deacetylase family. HD type 1 subfamily.

Protein post-translational modifications

Phosphorylated by PKA on serine 39. Phosphorylation reduces deacetylase activity observed preferentially on histones H3 and H4.

Protein cellular localization

Nucleus. Cytoplasm. Note=Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation.

Background

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Transcription-Regulators/">Transcription Regulators</a>><a href="http://antibodyplus.com/product-tag/HDAC8/">HDAC8</a><br><a href="http://antibodyplus.com/product-tag/Transcription-Regulators/"&gt; (View all antibody categories related to Transcription Regulators)</a>

Note

AntibodyPlus can customize Phospho-HDAC8-S39 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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