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Rabbit Polyclonal Phospho-HDAC8 (S39) antibody (STJ90287)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for HDAC8 (phospho Ser39) Polyclonal Antibody.
Check alternative names for the antibodyExpand
HDAC8 antibody, HDACL1 antibody, CDA07 antibody,|CDA07 antibody|CDLS5 antibody|HD 8 antibody|HD8 antibody|HDAC 8 antibody|Hdac8 antibody|HDAC8_HUMAN antibody|HDACL 1 antibody|HDACL1 antibody|Histone deacetylase 8 antibody|Histone deacetylase like 1 antibody|MRXS6 antibody|RPD 3 antibody|RPD3 antibody|WTS antibody|Anti-HDAC8 antibody [EPR10338(2)] (ab187139)
SCBT cat No: sc-365620|sc-17778|sc-374180|sc-11405|sc-56687|sc-11544|sc-398003|
HDAC8 (phospho Ser39) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-HDAC8 (S39) Polyclonal Antibody detects endogenous levels of HDAC8 protein only when phosphorylated at S39.
Synthesized phospho-peptide derived from HDAC8 (phospho Ser39) at AA range 20-100
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;
|Molecular weight|| |
HDAC8 (phospho Ser39) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
HDAC8 (phospho Ser39) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Histone deacetylase 8 antibody, HD8 antibody,
|Protein names|| |
Histone deacetylase 8 , HD8 ,
|Protein function|| |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. / Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. / a divalent metal cation / Its activity is inhibited by trichostatin A (TSA), suberoylanilide hydroxamic acid (SAHA), 3-(1-methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide (APHA), 4-dimethylamino-N-(6-hydroxycarbamoyethyl)benzamide-N-hydroxy-7-(4-dimethylaminobenzoyl)aminoheptanamide (MS-344), 5-(4-methyl-benzoylamino)-biphenyl-3,4′-dicarboxylic acid 3-dimethylamide 4′-hydroxyamide (CRA-A) and butyrate.
|Protein tissue specificity|| |
Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney.
|Involvement in disease|| |
Cornelia de Lange syndrome 5 (CDLS5) [MIM:300882]: A form of Cornelia de Lange syndrome, a clinically heterogeneous developmental disorder associated with malformations affecting multiple systems. It is characterized by facial dysmorphisms, abnormal hands and feet, growth delay, cognitive retardation, hirsutism, gastroesophageal dysfunction and cardiac, ophthalmologic and genitourinary anomalies. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Wilson-Turner X-linked mental retardation syndrome (WTS) [MIM:309585]: A neurologic disorder characterized by severe intellectual disability, dysmorphic facial features, hypogonadism, short stature, and truncal obesity. Affected females have a milder phenotype than affected males. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the histone deacetylase family. HD type 1 subfamily.
|Protein post-translational modifications|| |
Phosphorylated by PKA on serine 39. Phosphorylation reduces deacetylase activity observed preferentially on histones H3 and H4.
|Protein cellular localization|| |
Nucleus / Cytoplasm
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St John’s Laboratory Ltd.
|Product type|| |
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