Rabbit Polyclonal Phospho-hnRNP C1/2 (S260) antibody (STJ90910)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-hnRNP C1/2 (S260) antibody (STJ90910)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for hnRNP C1/2 (phospho Ser260) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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HNRNPC antibody, HNRPC antibody,|C1 antibody|PFD4 antibody|PFD4_HUMAN antibody|PFDN4 antibody|Prefoldin 4 antibody|Prefoldin subunit 4 antibody|Protein C-1 antibody|Protein C1 antibody|Anti-hnRNP C1 + C2 antibody [4F4] (ab10294)
SCBT cat No: sc-32308|sc-15386|sc-10037|

 

Name

hnRNP C1/2 (phospho Ser260) Polyclonal Antibody

Catalogue No.

STJ90910

Reactivity

Human, Mouse, Rat

Specificity

Phospho-hnRNP C1/2 (S260) Polyclonal Antibody detects endogenous levels of hnRNP C1/2 protein only when phosphorylated at S260.

Immunogen

Synthesized phospho-peptide derived from hnRNP C1/2 (phospho Ser260) at AA range 200-280

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

41 kDa

Formulation

hnRNP C1/2 (phospho Ser260) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

hnRNP C1/2 (phospho Ser260) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Heterogeneous nuclear ribonucleoproteins C1/C2 antibody, hnRNP C1/C2 antibody

Database links

Human UniProt/Swiss-Prot:P07910;Mouse UniPort/Swiss-Prot: Q9Z204;Rat UniProt/Swiss-Port: A0A0G2JXW4;Human Entrez Gene: 3183;Mouse Entrez Gene: 15381;Rat Entrez Gene: Rn.101929

Protein names

Heterogeneous nuclear ribonucleoproteins C1/C2 , hnRNP C1/C2

Protein function

Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles . Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named ‘m6A-switch’ to facilitate binding of HNRNPC, leading to regulation of mRNA splicing . Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3′-UTR or 5′-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules .

Protein sequence and domain

Belongs to the RRM HNRPC family. RALY subfamily. / Contains 1 RRM (RNA recognition motif) domain.

Protein post-translational modifications

Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide. / Sumoylated. Sumoylation reduces affinity for mRNA.

Protein cellular localization

Nucleus

Research area

All research areas>Transcription Regulators>hnRNP
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize hnRNP C1/2 (phospho Ser260) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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