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Rabbit Polyclonal Phospho-hnRNP C1/2 (S260) antibody (STJ90910)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for hnRNP C1/2 (phospho Ser260) Polyclonal Antibody.
Check alternative names for the antibodyExpand
HNRNPC antibody, HNRPC antibody,|C1 antibody|PFD4 antibody|PFD4_HUMAN antibody|PFDN4 antibody|Prefoldin 4 antibody|Prefoldin subunit 4 antibody|Protein C-1 antibody|Protein C1 antibody|Anti-hnRNP C1 + C2 antibody [4F4] (ab10294)
SCBT cat No: sc-32308|sc-15386|sc-10037|
hnRNP C1/2 (phospho Ser260) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-hnRNP C1/2 (S260) Polyclonal Antibody detects endogenous levels of hnRNP C1/2 protein only when phosphorylated at S260.
Synthesized phospho-peptide derived from hnRNP C1/2 (phospho Ser260) at AA range 200-280
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;
|Molecular weight|| |
hnRNP C1/2 (phospho Ser260) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
hnRNP C1/2 (phospho Ser260) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Heterogeneous nuclear ribonucleoproteins C1/C2 antibody, hnRNP C1/C2 antibody
|Protein names|| |
Heterogeneous nuclear ribonucleoproteins C1/C2 , hnRNP C1/C2
|Protein function|| |
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles . Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named ‘m6A-switch’ to facilitate binding of HNRNPC, leading to regulation of mRNA splicing . Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3′-UTR or 5′-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules .
|Protein sequence and domain|| |
Belongs to the RRM HNRPC family. RALY subfamily. / Contains 1 RRM (RNA recognition motif) domain.
|Protein post-translational modifications|| |
Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide. / Sumoylated. Sumoylation reduces affinity for mRNA.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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