Rabbit Polyclonal Phospho-Hrs (Y216) antibody (STJ90292)


Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-Hrs (Y216) antibody (STJ90292)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Hrs (phospho Tyr216) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody


HGS antibody, HRS antibody,|Hepatocyte growth factor regulated tyrosine kinase substrate antibody|Hepatocyte growth factor-regulated tyrosine kinase substrate antibody|HGF-regulated tyrosine kinase substrate antibody|HGNC:4897 antibody|HGS antibody|HGS_HUMAN antibody|Hrs antibody|Human growth factor regulated tyrosine kinase substrate antibody|Protein pp110 antibody|ZFYVE8 antibody|Anti-HGS antibody (ab56468)
SCBT cat No: sc-271455|sc-271160|sc-271925|sc-166843|sc-30221|sc-23791|



Hrs (phospho Tyr216) Polyclonal Antibody

Catalogue No.



Human, Mouse, Rat


Phospho-Hrs (Y216) Polyclonal Antibody detects endogenous levels of Hrs protein only when phosphorylated at Y216.


Synthesized phospho-peptide derived from human Hrs around the phosphorylation site of Y216





Recommended dilution

WB 1:500-1:2000; ELISA 1:10000;







Molecular weight

115 kDa


Hrs (phospho Tyr216) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.


1 mg/ml


Hrs (phospho Tyr216) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.


-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Hepatocyte growth factor-regulated tyrosine kinase substrate antibody, Hrs antibody, Protein pp110 antibody

Database links

Human UniProt/Swiss-Prot:O14964;Mouse UniPort/Swiss-Prot: Q99LI8;Rat UniProt/Swiss-Port: Q9JJ50;Human Entrez Gene: 9146;Mouse Entrez Gene: 15239;Rat Entrez Gene: Rn.21

Protein names

Hepatocyte growth factor-regulated tyrosine kinase substrate , Hrs , Protein pp110

Protein function

Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.

Protein tissue specificity

Ubiquitous expression in adult and fetal tissues with higher expression in testis and peripheral blood leukocytes.

Protein sequence and domain

Has a double-sided UIM that can bind 2 ubiquitin molecules, one on each side of the helix. / The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns3P-enriched membranes is substantially increased in acidic conditions. / Contains 1 FYVE-type zinc finger. / Contains 1 UIM (ubiquitin-interacting motif) domain. / Contains 1 VHS domain.

Protein post-translational modifications

Phosphorylated on Tyr-334. A minor site of phosphorylation on Tyr-329 is detected (By similarity). Phosphorylation occurs in response to EGF, IL-2, GM-CSF and HGF. / Ubiquitinated by ITCH.

Protein cellular localization

Cytoplasm / Early endosome membrane; Peripheral membrane protein; Cytoplasmic side / Endosome > multivesicular body membrane

Research area

All research areas>Transport and Trafficking>Hrs
(View all antibody categories related to Transport and Trafficking)


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St John’s Laboratory Ltd.

Product type

Primary antibody


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