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Rabbit Polyclonal Phospho-Hrs (Y216) antibody (STJ90292)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for Hrs (phospho Tyr216) Polyclonal Antibody.
Check alternative names for the antibodyExpand
HGS antibody, HRS antibody,|Hepatocyte growth factor regulated tyrosine kinase substrate antibody|Hepatocyte growth factor-regulated tyrosine kinase substrate antibody|HGF-regulated tyrosine kinase substrate antibody|HGNC:4897 antibody|HGS antibody|HGS_HUMAN antibody|Hrs antibody|Human growth factor regulated tyrosine kinase substrate antibody|Protein pp110 antibody|ZFYVE8 antibody|Anti-HGS antibody (ab56468)
SCBT cat No: sc-271455|sc-271160|sc-271925|sc-166843|sc-30221|sc-23791|
Hrs (phospho Tyr216) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-Hrs (Y216) Polyclonal Antibody detects endogenous levels of Hrs protein only when phosphorylated at Y216.
Synthesized phospho-peptide derived from human Hrs around the phosphorylation site of Y216
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000;
|Molecular weight|| |
Hrs (phospho Tyr216) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Hrs (phospho Tyr216) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Hepatocyte growth factor-regulated tyrosine kinase substrate antibody, Hrs antibody, Protein pp110 antibody
|Protein names|| |
Hepatocyte growth factor-regulated tyrosine kinase substrate , Hrs , Protein pp110
|Protein function|| |
Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
|Protein tissue specificity|| |
Ubiquitous expression in adult and fetal tissues with higher expression in testis and peripheral blood leukocytes.
|Protein sequence and domain|| |
Has a double-sided UIM that can bind 2 ubiquitin molecules, one on each side of the helix. / The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns3P-enriched membranes is substantially increased in acidic conditions. / Contains 1 FYVE-type zinc finger. / Contains 1 UIM (ubiquitin-interacting motif) domain. / Contains 1 VHS domain.
|Protein post-translational modifications|| |
Phosphorylated on Tyr-334. A minor site of phosphorylation on Tyr-329 is detected (By similarity). Phosphorylation occurs in response to EGF, IL-2, GM-CSF and HGF. / Ubiquitinated by ITCH.
|Protein cellular localization|| |
Cytoplasm / Early endosome membrane; Peripheral membrane protein; Cytoplasmic side / Endosome > multivesicular body membrane
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St John’s Laboratory Ltd.
|Product type|| |
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