Rabbit Polyclonal Phospho-IFN-gammaRalpha (Y457) antibody (STJ91086)

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Reactivity: Human, Mouse, Rat, Monkey
Applications: WB, IHC, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-IFN-gammaRalpha (Y457) antibody (STJ91086)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for IFN-gammaRalpha (phospho Tyr457) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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IFNGR1 antibody,|Antiviral Protein Type II antibody|Antiviral protein, type 2 antibody|AVP type II antibody|AVP, type 2 antibody|CD 119 antibody|CD119 antibody|CD119 antigen antibody|CDw119 antibody|FLJ45734 antibody|IFN gamma R alpha antibody|IFN gamma R antibody|IFN gamma R1 antibody|IFN-gamma receptor 1 antibody|IFN-gamma-R1 antibody|IFNG R1 antibody|IFNGR 1 antibody|IFNGR antibody|IFNGR1 antibody|Immune interferon receptor 1 antibody|Immune interferon receptor for antibody|INGR1_HUMAN antibody|Interferon gamma receptor 1 antibody|Interferon gamma receptor alpha chain antibody|Interferon gamma receptor alpha chain precursor antibody|Anti-IFNGR1 antibody (ab61179)
SCBT cat No: sc-74450|sc-12755|sc-703|

 

Name

IFN-gammaRalpha (phospho Tyr457) Polyclonal Antibody

Catalogue No.

STJ91086

Reactivity

Human, Mouse, Rat, Monkey

Specificity

Phospho-IFN-gammaRalpha (Y457) Polyclonal Antibody detects endogenous levels of IFN-gammaRalpha protein only when phosphorylated at Y457.

Immunogen

Synthesized phospho-peptide derived from IFN-gammaRalpha (phospho Tyr457) at AA range 400-480

Host

Rabbit

Applications

WB, IHC, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

83 kDa

Formulation

IFN-gammaRalpha (phospho Tyr457) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

IFN-gammaRalpha (phospho Tyr457) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Interferon gamma receptor 1 antibody, IFN-gamma receptor 1 antibody, IFN-gamma-R1 antibody, CDw119 antibody, CD antigen CD119 antibody

Database links

Human UniProt/Swiss-Prot:P15260;Mouse UniPort/Swiss-Prot: P15261;Rat UniProt/Swiss-Port: Q9QZ62;Human Entrez Gene: 3459;Mouse Entrez Gene: 15979;Rat Entrez Gene: Rn.19927

Protein names

Interferon gamma receptor 1 , IFN-gamma receptor 1 , IFN-gamma-R1 , CDw119 , CD antigen CD119

Protein function

Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) . Ligand binding stimulates activation of the JAK/STAT signaling pathway .

Involvement in disease

Immunodeficiency 27A (IMD27A) [MIM:209950]: A form of Mendelian susceptibility to mycobacterial disease, a rare condition caused by impairment of interferon-gamma mediated immunity. It is characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. Clinical outcome severity depends on the degree of impairment of interferon-gamma mediated immunity. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Immunodeficiency 27B (IMD27B) [MIM:615978]: A form of Mendelian susceptibility to mycobacterial disease, a rare condition caused by impairment of interferon-gamma mediated immunity. It is characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. Clinical outcome severity depends on the degree of impairment of interferon-gamma mediated immunity. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. IMD27B commonly presents with recurrent, moderately severe infections with environmental mycobacteria or BCG. Salmonellosis is present in about 5% of patients. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the type II cytokine receptor family. / Contains 2 fibronectin type-III domains. / Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Protein post-translational modifications

Phosphorylated at Ser/Thr residues.

Protein cellular localization

Cell membrane / Single-pass type I membrane protein

Research area

All research areas>Membrane Receptors>IFN-gamma R alpha
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize IFN-gammaRalpha (phospho Tyr457) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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