Rabbit Polyclonal Phospho-IFNAR1-S535/S539 antibody (AP0366)

$99.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit Polyclonal Phospho-IFNAR1-S535/S539 antibody (AP0366)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit Polyclonal Phospho-IFNAR1-S535/S539 antibody.

Alternative names:

Check alternative names for the antibody

Expand

AVP antibody; IFRC antibody; IFNAR antibody; IFNBR antibody; IFN-alpha-REC antibody;
Alpha type antiviral protein antibody|AVP antibody|Beta type antiviral protein antibody|CRF2-1 antibody|Cytokine receptor class-II member 1 antibody|Cytokine receptor family 2 member 1 antibody|IFN alpha REC antibody|IFN alpha receptor antibody|IFN alpha/beta Receptor alpha antibody|IFN beta receptor antibody|IFN-alpha/beta receptor 1 antibody|IFN-R-1 antibody|IFNAR antibody|Ifnar1 antibody|IFNBR antibody|IFRC antibody|INAR1_HUMAN antibody|Interferon (alpha beta and omega) receptor 1 antibody|Interferon alpha/beta receptor 1 antibody|Interferon alpha/beta receptor alpha chain antibody|Interferon beta receptor 1 antibody|Type I interferon receptor 1 antibody|Anti-IFNAR1 antibody [EP899Y] (ab45172)

SCBT cat No: sc-7391|sc-845|sc-704|sc-271105|

Name

Rabbit Polyclonal Phospho-IFNAR1-S535/S539 antibody

Catalogue No.

AP0366

Reactivity

Human

Immunogen

A phospho specific peptide corresponding to residues surrounding S535/S539 of human IFNAR1

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

70kDa

Formulation

Phospho-IFNAR1-S535/S539 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

AVP antibody; IFRC antibody; IFNAR antibody; IFNBR antibody; IFN-alpha-REC antibody;

Protein names

AVP; IFRC; IFNAR; IFNBR; IFN-alpha-REC;

Protein function

Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).

Protein tissue specificity

IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.

Protein sequence and domain

Belongs to the type II cytokine receptor family.; Contains 4 fibronectin type-III domains.

Protein post-translational modifications

Ubiquitinated, leading to its internalization and degradation (PubMed:14532120, PubMed:15337770). Polyubiquitinated via 'Lys-48'-linked and 'Lys-63'-linked ubiquitin chains, leading to receptor internalization and lysosomal degradation (PubMed:18056411). The 'Lys-63'-linked ubiquitin chains are cleaved off by the BRISC complex (PubMed:24075985).; Phosphorylated on serine residues in response to interferon binding; this promotes interaction with FBXW11 and ubiquitination (PubMed:14532120, PubMed:15337770, PubMed:24075985). Phosphorylated on tyrosine residues by TYK2 tyrosine kinase (PubMed:7526154). Phosphorylated on tyrosine residues in response to interferon (PubMed:10049744).; Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT2.

Protein cellular localization

Isoform 1: Cell membrane ; Single-pass type I membrane protein . Late endosome . Lysosome . Note=Interferon binding triggers internalization of the receptor from the cell membrane into endosomes and then into lysosomes.

Background

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Membrane-Receptors/">Membrane Receptors</a>><a href="http://antibodyplus.com/product-tag/Interferon-Receptor/">Interferon Receptor</a><br><a href="http://antibodyplus.com/product-tag/Membrane-Receptors/"&gt; (View all antibody categories related to Membrane Receptors)</a>

Note

AntibodyPlus can customize Phospho-IFNAR1-S535/S539 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below: