Rabbit Polyclonal Phospho-IL-4Ralpha (Y497) antibody (STJ90720)

$99.00$319.00

Reactivity: Human, Mouse
Applications: WB, IHC, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-IL-4Ralpha (Y497) antibody (STJ90720)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for IL-4Ralpha (phospho Tyr497) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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IL4R antibody, IL4RA antibody, 582J2.1 antibody,|CD124 antibody|IL 4R alpha antibody|IL-4 receptor subunit alpha antibody|IL-4-binding protein antibody|IL-4R subunit alpha antibody|IL-4R-alpha antibody|IL-4RA antibody|IL4-BP antibody|Il4r antibody|IL4R nirs variant 1 antibody|IL4RA antibody|IL4RA_HUMAN antibody|Interleukin 4 receptor alpha chain antibody|Interleukin 4 receptor antibody|sIL4Ralpha/prot antibody|Soluble IL-4 receptor subunit alpha antibody|Soluble IL-4R-alpha antibody|Soluble interleukin-4 receptor subunit alpha antibody|Anti-IL4R antibody (ab203398)
SCBT cat No: sc-137257|sc-165974|sc-137256|sc-25473|

 

Name

IL-4Ralpha (phospho Tyr497) Polyclonal Antibody

Catalogue No.

STJ90720

Reactivity

Human, Mouse

Specificity

Phospho-IL-4Ralpha (Y497) Polyclonal Antibody detects endogenous levels of IL-4Ralpha protein only when phosphorylated at Y497.

Immunogen

Synthesized phospho-peptide derived from IL-4Ralpha (phospho Tyr497) at AA range 440-520

Host

Rabbit

Applications

WB, IHC, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

90 kDa

Formulation

IL-4Ralpha (phospho Tyr497) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

IL-4Ralpha (phospho Tyr497) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Interleukin-4 receptor subunit alpha antibody, IL-4 receptor subunit alpha antibody, IL-4R subunit alpha antibody, IL-4R-alpha antibody, IL-4RA antibody, CD antigen CD124 antibody

Database links

Human UniProt/Swiss-Prot:P24394;Mouse UniPort/Swiss-Prot: P16382;Rat UniProt/Swiss-Port: Q63257;Human Entrez Gene: 3566;Mouse Entrez Gene: 16190;Rat Entrez Gene: Rn.10471

Protein names

Interleukin-4 receptor subunit alpha , IL-4 receptor subunit alpha , IL-4R subunit alpha , IL-4R-alpha , IL-4RA , CD antigen CD124

Protein function

Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. / Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.

Protein tissue specificity

Isoform 1 and isoform 2 are highly expressed in activated T-cells.

Protein sequence and domain

The extracellular domain represents the IL4 binding protein (IL4BP). / The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. / The box 1 motif is required for JAK interaction and/or activation. / Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. / Belongs to the type I cytokine receptor family. Type 4 subfamily. / Contains 1 fibronectin type-III domain.

Protein post-translational modifications

On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction. / The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase.

Protein cellular localization

Cell membrane; Single-pass type I membrane protein / Secreted

Research area

All research areas>Membrane Receptors>IL-2/-4/-7/-9/-13/-15 Receptor Complex
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize IL-4Ralpha (phospho Tyr497) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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