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Rabbit Polyclonal Phospho-IL-7R (Y449) antibody (STJ90721)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for IL-7R (phospho Tyr449) Polyclonal Antibody.
Check alternative names for the antibodyExpand
IL7R antibody,|CD 127 antibody|CD127 antibody|CD127 antigen antibody|CDw127 antibody|IL 7R alpha antibody|IL 7R antibody|IL-7 receptor subunit alpha antibody|IL-7R subunit alpha antibody|IL-7R-alpha antibody|IL-7RA antibody|IL7R antibody|IL7RA antibody|IL7RA_HUMAN antibody|IL7Ralpha antibody|ILRA antibody|Interleukin 7 receptor alpha chain antibody|Interleukin 7 receptor antibody|Interleukin 7 receptor isoform H5 6 antibody|Interleukin-7 receptor subunit alpha antibody|Anti-IL7R alpha antibody [EPR2955(2)] (ab180521)
SCBT cat No: sc-662|sc-31341|sc-514445|sc-25475|sc-31343|
IL-7R (phospho Tyr449) Polyclonal Antibody
|Catalogue No.|| |
Phospho-IL-7R (Y449) Polyclonal Antibody detects endogenous levels of IL-7R protein only when phosphorylated at Y449.
Synthesized phospho-peptide derived from IL-7R (phospho Tyr449) at AA range 380-460
WB, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000;
|Molecular weight|| |
IL-7R (phospho Tyr449) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
IL-7R (phospho Tyr449) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Interleukin-7 receptor subunit alpha antibody, IL-7 receptor subunit alpha antibody, IL-7R subunit alpha antibody, IL-7R-alpha antibody, IL-7RA antibody, CDw127 antibody, CD antigen CD127 antibody
|Protein names|| |
Interleukin-7 receptor subunit alpha , IL-7 receptor subunit alpha , IL-7R subunit alpha , IL-7R-alpha , IL-7RA , CDw127 , CD antigen CD127
|Protein function|| |
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
|Involvement in disease|| |
Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]: A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. Note: The disease is caused by mutations affecting the gene represented in this entry.; Multiple sclerosis 3 (MS3) [MIM:612595]: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. A polymorphism at position 244 strongly influences susceptibility to multiple sclerosis. Overtransmission of the major ‘C’ allele coding for Thr-244 is detected in offspring affected with multiple sclerosis. In vitro analysis of transcripts from minigenes containing either ‘C’ allele (Thr-244) or ‘T’ allele (Ile-244) shows that the ‘C’ allele results in an approximately two-fold increase in the skipping of exon 6, leading to increased production of a soluble form of IL7R. Thus, the multiple sclerosis associated ‘C’ risk allele of IL7R would probably decrease membrane-bound expression of IL7R. As this risk allele is common in the general population, some additional triggers are probably required for the development and progression of MS.
|Protein sequence and domain|| |
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. / The box 1 motif is required for JAK interaction and/or activation. / Belongs to the type I cytokine receptor family. Type 4 subfamily. / Contains 1 fibronectin type-III domain.
|Protein post-translational modifications|| |
N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form.
|Protein cellular localization|| |
Cell membrane; Single-pass type I membrane protein / Cell membrane; Single-pass type I membrane protein / Secreted
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St John’s Laboratory Ltd.
|Product type|| |
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