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Rabbit Polyclonal Phospho-Integrin beta1 (T789) antibody (STJ91039)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for Integrin beta1 (phospho Thr789) Polyclonal Antibody.
Check alternative names for the antibodyExpand
ITGB1 antibody, FNRB antibody, MDF2 antibody, MSK12 antibody,|beta1 integrin antibody|CD29 antibody|Fibronectin receptor subunit beta antibody|FNRB antibody|Glycoprotein IIa antibody|GP IIa antibody|GPIIA antibody|Integrin beta-1 antibody|integrin VLA-4 beta subunit antibody|Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) antibody|ITB1_HUMAN antibody|ITGB1 antibody|MDF2 antibody|MSK12 antibody|OTTHUMP00000019420 antibody|Very late activation protein, beta polypeptide antibody|VLA BETA antibody|VLA-4 subunit beta antibody|VLA-BETA antibody|VLAB antibody|VLAbeta antibody|Anti-Integrin beta 1 antibody [EP1041Y] (ab52971)
SCBT cat No: sc-71428|sc-59969|sc-164679|sc-19981|sc-53357|sc-28662|sc-6606|sc-6607|sc-21773|sc-373992|sc-166599|sc-365938|sc-6602|sc-15328|sc-6604|sc-7310|sc-19963|sc-52816|sc-21783|sc-53358|
Integrin beta1 (phospho Thr789) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-Integrin beta1 (T789) Polyclonal Antibody detects endogenous levels of Integrin beta1 protein only when phosphorylated at T789.
Synthesized phospho-peptide derived from Integrin beta1 (phospho Thr789) at AA range 720-800
WB, IHC, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000;
|Molecular weight|| |
Integrin beta1 (phospho Thr789) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Integrin beta1 (phospho Thr789) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Integrin beta-1 antibody, Fibronectin receptor subunit beta antibody, Glycoprotein IIa antibody, GPIIA antibody, VLA-4 subunit beta antibody, CD antigen CD29 antibody
|Protein names|| |
Integrin beta-1 , Fibronectin receptor subunit beta , Glycoprotein IIa , GPIIA , VLA-4 subunit beta , CD antigen CD29
|Protein function|| |
Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. / Isoform 5: Isoform 5 displaces isoform 1 in striated muscles. / (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 . Acts as a receptor for cytomegalovirus/HHV-5 . Acts as a receptor for Epstein-Barr virus/HHV-4 . Integrin ITGA5:ITGB1 acts as a receptor for human parvovirus B19 . Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus . Acts as a receptor for mammalian reovirus . In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposi’s sarcoma lesions .
|Protein tissue specificity|| |
Isoform 1 is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform 2 is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform 3 and isoform 4 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform 4, rather than isoform 3, is selectively expressed in peripheral T-cells. Isoform 3 is expressed in non-proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines. Isoform 5 is expressed specifically in striated muscle (skeletal and cardiac muscle).
|Protein sequence and domain|| |
Belongs to the integrin beta chain family. / Contains 1 VWFA domain.
|Protein post-translational modifications|| |
The cysteine residues are involved in intrachain disulfide bonds.
|Protein cellular localization|| |
Cell membrane / Single-pass type I membrane protein / Cell projection > invadopodium membrane / Single-pass type I membrane protein / Cell projection > ruffle membrane / Single-pass type I membrane protein / Recycling endosome / Melanosome / Cleavage furrow / Cell projection > lamellipodium / Cell projection > ruffle / Cell membrane > sarcolemma / Cell junction
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St John’s Laboratory Ltd.
|Product type|| |
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