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Rabbit Polyclonal Phospho-Integrin beta3 (Y785) antibody (STJ90684)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for Integrin beta3 (phospho Tyr785) Polyclonal Antibody.
Check alternative names for the antibodyExpand
ITGB3 antibody, GP3A antibody,|BDPLT16 antibody|BDPLT2 antibody|CD 61 antibody|CD61 antibody|CD61 antigen antibody|GP3A antibody|GPIIIa antibody|GT antibody|HPA 1 antibody|HPA 4 antibody|Integrin beta 3 (platelet glycoprotein IIIa antigen CD61) antibody|Integrin beta chain beta 3 antibody|Integrin beta-3 antibody|ITB3_HUMAN antibody|ITG B3 antibody|ITGB 3 antibody|ITGB3 antibody|NAIT antibody|Platelet fibrinogen receptor beta subunit antibody|Platelet fibrinogen receptor, beta subunit antibody|Platelet glycoprotein IIIa antibody|Platelet glycoprotein IIIa precursor antibody|Platelet membrane glycoprotein IIIa antibody|PTP antibody|Anti-Integrin beta 3 antibody [EPR2342] (ab119992)
SCBT cat No: sc-7312|sc-52684|sc-81632|sc-13588|sc-59970|sc-59971|sc-71453|sc-71454|sc-71455|sc-1185|sc-71456|sc-46676|sc-19989|sc-19618|sc-6619|sc-398708|sc-26692|sc-398725|
Integrin beta3 (phospho Tyr785) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-Integrin beta3 (Y785) Polyclonal Antibody detects endogenous levels of Integrin beta3 protein only when phosphorylated at Y785.
Synthesized phospho-peptide derived from Integrin beta3 (phospho Tyr785) at AA range 720-800
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000;
|Molecular weight|| |
Integrin beta3 (phospho Tyr785) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Integrin beta3 (phospho Tyr785) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Integrin beta-3 antibody, Platelet membrane glycoprotein IIIa antibody, GPIIIa antibody, CD antigen CD61 antibody
|Protein names|| |
Integrin beta-3 , Platelet membrane glycoprotein IIIa , GPIIIa , CD antigen CD61
|Protein function|| |
Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). / (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for herpes virus 8/HHV-8 . Integrin ITGAV:ITGB3 acts as a receptor for coxsackievirus A9 . Acts as a receptor for Hantaan virus . Integrin ITGAV:ITGB3 acts as a receptor for cytomegalovirus/HHV-5 . Integrin ITGA5:ITGB3 acts as a receptor for human metapneumovirus . Integrin ITGAV:ITGB3 acts aP05556s a receptor for human parechovirus 1 . Integrin ITGAV:ITGB3 acts as a receptor for west nile virus . In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi’s sarcoma lesions .
|Protein tissue specificity|| |
Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.
|Involvement in disease|| |
Glanzmann thrombasthenia (GT) [MIM:273800]: A common inherited disease of platelet aggregation. It is characterized by mucocutaneous bleeding of mild-to-moderate severity. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels, have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Bleeding disorder, platelet-type 16 (BDPLT16) [MIM:187800]: An autosomal dominant form of congenital macrothrombocytopenia associated with platelet anisocytosis. It is a disorder of platelet production. Affected individuals may have no or only mildly increased bleeding tendency. In vitro studies show mild platelet functional abnormalities. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the integrin beta chain family. / Contains 1 VWFA domain.
|Protein post-translational modifications|| |
Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are phosphorylated. Phosphorylation of Thr-779 inhibits SHC binding.
|Protein cellular localization|| |
Cell membrane / Single-pass type I membrane protein / Cell projection > lamellipodium membrane / Cell junction > focal adhesion
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St John’s Laboratory Ltd.
|Product type|| |
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