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Rabbit Polyclonal Phospho-Integrin beta4 (Y1510) antibody (STJ90915)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for Integrin beta4 (phospho Tyr1510) Polyclonal Antibody.
Check alternative names for the antibodyExpand
ITGB4 antibody,|CD 104 antibody|CD104 antibody|CD104 antigen antibody|gp150 antibody|Integrin beta 4 subunit antibody|Integrin beta-4 antibody|ITB4_HUMAN antibody|ITG B4 antibody|ITGB 4 antibody|Itgb4 antibody|Anti-Integrin beta 4 antibody [M126] (ab29042)
SCBT cat No: sc-135950|sc-13543|sc-377523|sc-514426|sc-6628|sc-514252|sc-13127|sc-55514|sc-9090|
Integrin beta4 (phospho Tyr1510) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-Integrin beta4 (Y1510) Polyclonal Antibody detects endogenous levels of Integrin beta4 protein only when phosphorylated at Y1510.
Synthesized phospho-peptide derived from Integrin beta4 (phospho Tyr1510) at AA range 1450-1530
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
|Molecular weight|| |
Integrin beta4 (phospho Tyr1510) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Integrin beta4 (phospho Tyr1510) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Integrin beta-4 antibody, GP150 antibody, CD antigen CD104 antibody
|Protein names|| |
Integrin beta-4 , GP150 , CD antigen CD104
|Protein function|| |
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility.
|Protein tissue specificity|| |
Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.
|Involvement in disease|| |
Epidermolysis bullosa letalis, with pyloric atresia (EB-PA) [MIM:226730]: An autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Generalized atrophic benign epidermolysis bullosa (GABEB) [MIM:226650]: A non-lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The fibronectin type-III-like domains bind BPAG1 and plectin and probably also recruit BP230. / Belongs to the integrin beta chain family. / Contains 1 Calx-beta domain. / Contains 4 fibronectin type-III domains. / Contains 1 PSI domain. / Contains 1 VWFA domain.
|Protein post-translational modifications|| |
Palmitoylated by DHHC3 at several cysteines of the membrane-proximal region, enhancing stability and cell surface expression. Palmitoylation also promotes secundary association with tertaspanins.
|Protein cellular localization|| |
Cell membrane; Single-pass type I membrane protein / Cell membrane; Lipid-anchor / Cell junction > hemidesmosome
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St John’s Laboratory Ltd.
|Product type|| |
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