Rabbit Polyclonal Phospho-Integrin beta4 (Y1510) antibody (STJ90915)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-Integrin beta4 (Y1510) antibody (STJ90915)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Integrin beta4 (phospho Tyr1510) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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ITGB4 antibody,|CD 104 antibody|CD104 antibody|CD104 antigen antibody|gp150 antibody|Integrin beta 4 subunit antibody|Integrin beta-4 antibody|ITB4_HUMAN antibody|ITG B4 antibody|ITGB 4 antibody|Itgb4 antibody|Anti-Integrin beta 4 antibody [M126] (ab29042)
SCBT cat No: sc-135950|sc-13543|sc-377523|sc-514426|sc-6628|sc-514252|sc-13127|sc-55514|sc-9090|

 

Name

Integrin beta4 (phospho Tyr1510) Polyclonal Antibody

Catalogue No.

STJ90915

Reactivity

Human, Mouse, Rat

Specificity

Phospho-Integrin beta4 (Y1510) Polyclonal Antibody detects endogenous levels of Integrin beta4 protein only when phosphorylated at Y1510.

Immunogen

Synthesized phospho-peptide derived from Integrin beta4 (phospho Tyr1510) at AA range 1450-1530

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

202 kDa

Formulation

Integrin beta4 (phospho Tyr1510) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Integrin beta4 (phospho Tyr1510) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Integrin beta-4 antibody, GP150 antibody, CD antigen CD104 antibody

Database links

Human UniProt/Swiss-Prot:P16144;Mouse UniPort/Swiss-Prot: A2A863;Rat UniProt/Swiss-Port: Q64632;Human Entrez Gene: 3691;Mouse Entrez Gene: 192897;Rat Entrez Gene: Rn.198908

Protein names

Integrin beta-4 , GP150 , CD antigen CD104

Protein function

Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility.

Protein tissue specificity

Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.

Involvement in disease

Epidermolysis bullosa letalis, with pyloric atresia (EB-PA) [MIM:226730]: An autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Generalized atrophic benign epidermolysis bullosa (GABEB) [MIM:226650]: A non-lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

The fibronectin type-III-like domains bind BPAG1 and plectin and probably also recruit BP230. / Belongs to the integrin beta chain family. / Contains 1 Calx-beta domain. / Contains 4 fibronectin type-III domains. / Contains 1 PSI domain. / Contains 1 VWFA domain.

Protein post-translational modifications

Palmitoylated by DHHC3 at several cysteines of the membrane-proximal region, enhancing stability and cell surface expression. Palmitoylation also promotes secundary association with tertaspanins.

Protein cellular localization

Cell membrane; Single-pass type I membrane protein / Cell membrane; Lipid-anchor / Cell junction > hemidesmosome

Research area

All research areas>Cell Adhesion Proteins>Integrin beta 4
(View all antibody categories related to Cell Adhesion Proteins)

Note

AntibodyPlus can customize Integrin beta4 (phospho Tyr1510) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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