Rabbit Polyclonal Phospho-IRS-1 (S312) antibody (STJ90731)


Reactivity: Human, Mouse, Rat
Applications: WB, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-IRS-1 (S312) antibody (STJ90731)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for IRS-1 (phospho Ser312) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody


IRS1 antibody,|HIRS 1 antibody|HIRS1 antibody|Insulin receptor substrate 1 antibody|IRS 1 antibody|IRS-1 antibody|IRS1 antibody|IRS1_HUMAN antibody|OTTHUMP00000164234 antibody|Anti-IRS1 antibody [EP263Y] (ab40777)
SCBT cat No: sc-560|sc-559|sc-8038|sc-7200|sc-515017|sc-1556|sc-390761|sc-8299|sc-1555|sc-28831|sc-373778|sc-8189|sc-393207|sc-28830|sc-100854|sc-136470|sc-50008|sc-134810|sc-50011|



IRS-1 (phospho Ser312) Polyclonal Antibody

Catalogue No.



Human, Mouse, Rat


Phospho-IRS-1 (S312) Polyclonal Antibody detects endogenous levels of IRS-1 protein only when phosphorylated at S312.


Synthesized phospho-peptide derived from IRS-1 (phospho Ser312) at AA range 250-330





Recommended dilution

WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:20000;







Molecular weight

170/132 kDa


IRS-1 (phospho Ser312) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.


1 mg/ml


IRS-1 (phospho Ser312) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.


-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Insulin receptor substrate 1 antibody, IRS-1 antibody

Database links

Human UniProt/Swiss-Prot:P35568;Mouse UniPort/Swiss-Prot: P35569;Rat UniProt/Swiss-Port: P35570;Human Entrez Gene: 3667;Mouse Entrez Gene: 16367;Rat Entrez Gene: Rn.10476

Protein names

Insulin receptor substrate 1 , IRS-1

Protein function

May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).

Involvement in disease

Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body’s own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. . Note: The gene represented in this entry may be involved in disease pathogenesis.

Protein sequence and domain

Contains 1 IRS-type PTB domain. / Contains 1 PH domain.

Protein post-translational modifications

Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor (By similarity). Phosphorylation of Tyr-896 is required for GRB2-binding (By similarity). Phosphorylated by ALK. Phosphorylated at Ser-270, Ser-307, Ser-636 and Ser-1101 by RPS6KB1; phosphorylation induces accelerated degradation of IRS1. / Ubiquitinated by the Cul7-RING(FBXW8) complex in a mTOR-dependent manner, leading to its degradation: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2).

Research area

All research areas>Signaling Intermediates>IRS
(View all antibody categories related to Signaling Intermediates)


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St John’s Laboratory Ltd.

Product type

Primary antibody


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