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Rabbit Polyclonal Phospho-IRS-1 (S639) antibody (STJ90309)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for IRS-1 (phospho Ser639) Polyclonal Antibody.
Check alternative names for the antibodyExpand
IRS1 antibody,|HIRS 1 antibody|HIRS1 antibody|Insulin receptor substrate 1 antibody|IRS 1 antibody|IRS-1 antibody|IRS1 antibody|IRS1_HUMAN antibody|OTTHUMP00000164234 antibody|Anti-IRS1 antibody [EP263Y] (ab40777)
SCBT cat No: sc-560|sc-559|sc-8038|sc-7200|sc-515017|sc-1556|sc-390761|sc-8299|sc-1555|sc-28831|sc-373778|sc-8189|sc-393207|sc-28830|sc-100854|sc-136470|sc-50008|sc-134810|sc-50011|
IRS-1 (phospho Ser639) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-IRS-1 (S639) Polyclonal Antibody detects endogenous levels of IRS-1 protein only when phosphorylated at S639.
Synthesized phospho-peptide derived from IRS-1 (phospho Ser639) at AA range 580-660
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;
|Molecular weight|| |
IRS-1 (phospho Ser639) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
IRS-1 (phospho Ser639) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Insulin receptor substrate 1 antibody, IRS-1 antibody
|Protein names|| |
Insulin receptor substrate 1 , IRS-1
|Protein function|| |
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
|Involvement in disease|| |
Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body’s own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. . Note: The gene represented in this entry may be involved in disease pathogenesis.
|Protein sequence and domain|| |
Contains 1 IRS-type PTB domain. / Contains 1 PH domain.
|Protein post-translational modifications|| |
Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor (By similarity). Phosphorylation of Tyr-896 is required for GRB2-binding (By similarity). Phosphorylated by ALK. Phosphorylated at Ser-270, Ser-307, Ser-636 and Ser-1101 by RPS6KB1; phosphorylation induces accelerated degradation of IRS1. / Ubiquitinated by the Cul7-RING(FBXW8) complex in a mTOR-dependent manner, leading to its degradation: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2).
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St John’s Laboratory Ltd.
|Product type|| |
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