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Rabbit Polyclonal Phospho-IRS1-S312 antibody (AP0181)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:500 – 1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit Polyclonal Phospho-IRS1-S312 antibody.
Check alternative names for the antibodyExpand
HIRS 1 antibody|HIRS1 antibody|Insulin receptor substrate 1 antibody|IRS 1 antibody|IRS-1 antibody|IRS1 antibody|IRS1_HUMAN antibody|OTTHUMP00000164234 antibody|Anti-IRS1 antibody [EP263Y] (ab40777)
SCBT cat No: sc-560|sc-559|sc-8038|sc-7200|sc-515017|sc-1556|sc-390761|sc-8299|sc-1555|sc-28831|sc-373778|sc-8189|sc-393207|sc-28830|sc-100854|sc-136470|sc-50008|sc-134810|sc-50011|
Rabbit Polyclonal Phospho-IRS1-S312 antibody
|Catalogue No.|| |
A phospho specific peptide corresponding to residues surrounding S312 of human IRS1
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Phospho-IRS1-S312 antibody was tube-contained.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
Human UniProt/Swiss-Prot:<a href="http://www.uniprot.org/uniprot/P35568">P35568</a>
|Protein names|| |
|Protein function|| |
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
|Protein sequence and domain|| |
Contains 1 IRS-type PTB domain.; Contains 1 PH domain.
|Protein post-translational modifications|| |
Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor (By similarity). Phosphorylation of Tyr-896 is required for GRB2-binding (By similarity). Phosphorylated by ALK. Phosphorylated at Ser-270, Ser-307, Ser-636 and Ser-1101 by RPS6KB1; phosphorylation induces accelerated degradation of IRS1.; Ubiquitinated by the Cul7-RING(FBXW8) complex in a mTOR-dependent manner, leading to its degradation: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2).
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Signaling-Intermediates/">Signaling Intermediates</a>><a href="http://antibodyplus.com/product-tag/IRS/">IRS</a><br><a href="http://antibodyplus.com/product-tag/Signaling-Intermediates/"> (View all antibody categories related to Signaling Intermediates)</a>
AntibodyPlus can customize Phospho-IRS1-S312 antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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