Rabbit Polyclonal Phospho-ITGB3-Y773 antibody (AP0372)

$99.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-ITGB3-Y773 antibody (AP0372)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:1000
IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit Polyclonal Phospho-ITGB3-Y773 antibody.

Alternative names:

Check alternative names for the antibody

Expand

CD61 antigen antibody; GP3A antibody; GPIIIa antibody; ITB3 antibody; Platelet membrane glycoprotein IIIa antibody;
BDPLT16 antibody|BDPLT2 antibody|CD 61 antibody|CD61 antibody|CD61 antigen antibody|GP3A antibody|GPIIIa antibody|GT antibody|HPA 1 antibody|HPA 4 antibody|Integrin beta 3 (platelet glycoprotein IIIa antigen CD61) antibody|Integrin beta chain beta 3 antibody|Integrin beta-3 antibody|ITB3_HUMAN antibody|ITG B3 antibody|ITGB 3 antibody|ITGB3 antibody|NAIT antibody|Platelet fibrinogen receptor beta subunit antibody|Platelet fibrinogen receptor, beta subunit antibody|Platelet glycoprotein IIIa antibody|Platelet glycoprotein IIIa precursor antibody|Platelet membrane glycoprotein IIIa antibody|PTP antibody|Anti-Integrin beta 3 antibody [EPR2342] (ab119992)

SCBT cat No: sc-7312|sc-52684|sc-81632|sc-13588|sc-59970|sc-59971|sc-71453|sc-71454|sc-71455|sc-1185|sc-71456|sc-46676|sc-19989|sc-19618|sc-6619|sc-398708|sc-26692|sc-398725|

Name

Rabbit Polyclonal Phospho-ITGB3-Y773 antibody

Catalogue No.

AP0372

Reactivity

Human, Mouse

Immunogen

A phospho specific peptide corresponding to residues surrounding Y773 of human ITGB3

Host

Rabbit

Applications

WB, IHC

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

110kDa

Formulation

Phospho-ITGB3-Y773 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CD61 antigen antibody; GP3A antibody; GPIIIa antibody; ITB3 antibody; Platelet membrane glycoprotein IIIa antibody;

Protein names

CD61 antigen; GP3A; GPIIIa; ITB3; Platelet membrane glycoprotein IIIa;

Protein function

Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887).; (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for herpes virus 8/HHV-8 (PubMed:18045938). Integrin ITGAV:ITGB3 acts as a receptor for coxsackievirus A9 (PubMed:7519807). Acts as a receptor for Hantaan virus (PubMed:9618541). Integrin ITGAV:ITGB3 acts as a receptor for cytomegalovirus/HHV-5 (PubMed:15834425). Integrin ITGA5:ITGB3 acts as a receptor for human metapneumovirus (PubMed:24478423). Integrin ITGAV:ITGB3 acts aP05556s a receptor for human parechovirus 1 (PubMed:11160695). Integrin ITGAV:ITGB3 acts as a receptor for west nile virus (PubMed:23658209). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions (PubMed:10397733).

Protein tissue specificity

Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.

Protein sequence and domain

Belongs to the integrin beta chain family.; Contains 1 VWFA domain.

Protein post-translational modifications

Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are phosphorylated. Phosphorylation of Thr-779 inhibits SHC binding.

Protein cellular localization

Cell membrane ; Single-pass type I membrane protein . Cell projection, lamellipodium membrane . Cell junction, focal adhesion .

Background

Integrin a-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin a-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins a-IIb/beta-3 and a-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin a-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin a-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Cell-Adhesion-Proteins/">Cell Adhesion Proteins</a>><a href="http://antibodyplus.com/product-tag/Integrin/">Integrin</a><br><a href="http://antibodyplus.com/product-tag/Cell-Adhesion-Proteins/"&gt; (View all antibody categories related to Cell Adhesion Proteins)</a>

Note

AntibodyPlus can customize Phospho-ITGB3-Y773 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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