Rabbit Polyclonal Phospho-KIR6.2 (T224) antibody (STJ90722)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, IHC, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-KIR6.2 (T224) antibody (STJ90722)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for KIR6.2 (phospho Thr224) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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KCNJ11 antibody,|ATP sensitive inward rectifier potassium channel 11 antibody|Beta cell inward rectifier subunit antibody|BIR antibody|HHF 2 antibody|HHF2 antibody|IKATP antibody|Inward rectifier K(+) channel Kir6.2 antibody|Inwardly rectifying potassium channel KIR6.2 antibody|IRK 11 antibody|IRK11 antibody|KCNJ11 antibody|Kir 6.2 antibody|Kir6.2 antibody|MGC133230 antibody|PHHI antibody|Potassium channel inwardly rectifing subfamily J member 11 antibody|Potassium channel, inwardly rectifying subfamily J member 11 antibody|Potassium inwardly rectifying channel J11 antibody|TNDM 3 antibody|TNDM3 antibody|Anti-Kir6.2 antibody (ab79171)
SCBT cat No: sc-390104|sc-392198|sc-11228|sc-20809|sc-11226|

 

Name

KIR6.2 (phospho Thr224) Polyclonal Antibody

Catalogue No.

STJ90722

Reactivity

Human, Mouse, Rat

Specificity

Phospho-KIR6.2 (T224) Polyclonal Antibody detects endogenous levels of KIR6.2 protein only when phosphorylated at T224.

Immunogen

Synthesized phospho-peptide derived from KIR62 (phospho Thr224) at AA range 160-240

Host

Rabbit

Applications

WB, IHC, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

40 kDa

Formulation

KIR6.2 (phospho Thr224) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

KIR6.2 (phospho Thr224) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

ATP-sensitive inward rectifier potassium channel 11 antibody, IKATP antibody, Inward rectifier Kantibody, + antibody, channel Kir6.2 antibody, Potassium channel, inwardly rectifying subfamily J member 11 antibody

Database links

Human UniProt/Swiss-Prot:Q14654;Mouse UniPort/Swiss-Prot: Q61743;Rat UniProt/Swiss-Port: P70673;Human Entrez Gene: 3767;Mouse Entrez Gene: 16514;Rat Entrez Gene: Rn.3985

Protein names

ATP-sensitive inward rectifier potassium channel 11 , IKATP , Inward rectifier K, + , channel Kir6.2 , Potassium channel, inwardly rectifying subfamily J member 11

Protein function

This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.

Involvement in disease

Familial hyperinsulinemic hypoglycemia 2 (HHF2) [MIM:601820]: Most common cause of persistent hypoglycemia in infancy. Unless early and aggressive intervention is undertaken, brain damage from recurrent episodes of hypoglycemia may occur. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Diabetes mellitus, permanent neonatal (PNDM) [MIM:606176]: A rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Transient neonatal diabetes mellitus 3 (TNDM3) [MIM:610582]: Neonatal diabetes mellitus, defined as insulin-requiring hyperglycemia within the first month of life, is a rare entity. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes. In a significant number of patients with transient neonatal diabetes mellitus, diabetes type 2 appears later in life. The onset and severity of TNDM3 is variable with childhood-onset diabetes, gestational diabetes or adult-onset diabetes described. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Note: Defects in KCNJ11 may contribute to non-insulin-dependent diabetes mellitus (NIDDM), also known as diabetes mellitus type 2.; Maturity-onset diabetes of the young 13 (MODY13) [MIM:616329]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily. [View classification]

Protein post-translational modifications

Phosphorylation by MAPK1 results in changes in channel gating that destabilize the closed states and reduce the ATP sensitivity.

Protein cellular localization

Membrane; Multi-pass membrane protein

Research area

All research areas>Channel Proteins>KIR6.2
(View all antibody categories related to Channel Proteins)

Note

AntibodyPlus can customize KIR6.2 (phospho Thr224) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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