Rabbit Polyclonal Phospho-KRT18-S33 antibody (AP0263)

$99.00$259.00

Reactivity: Human
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit Polyclonal Phospho-KRT18-S33 antibody (AP0263)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:1000
IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit Polyclonal Phospho-KRT18-S33 antibody.

Alternative names:

Check alternative names for the antibody

Expand

K18 antibody; CYK18 antibody;
Cell proliferation inducing gene 46 protein antibody|Cell proliferation inducing protein 46 antibody|Cell proliferation-inducing gene 46 protein antibody|CK 18 antibody|CK-18 antibody|CK18 antibody|CYK 18 antibody|CYK18 antibody|Cytokeratin 18 antibody|Cytokeratin endo B antibody|Cytokeratin-18 antibody|K 18 antibody|K18 antibody|K1C18_HUMAN antibody|KA18 antibody|Keratin 18 antibody|Keratin 18, type I antibody|Keratin D antibody|keratin, type I cytoskeletal 18 antibody|Keratin-18 antibody|Krt18 antibody|Anti-Cytokeratin 18 antibody [C-04] (ab668)

SCBT cat No: sc-53254|sc-377224|sc-271937|sc-53255|sc-70915|sc-393091|sc-58726|sc-393002|sc-366511|sc-101461|sc-101931|sc-70917|sc-58727|sc-398871|sc-51582|sc-51583|sc-6259|sc-28264|sc-53256|sc-31700|sc-31701|sc-32722|

Name

Rabbit Polyclonal Phospho-KRT18-S33 antibody

Catalogue No.

AP0263

Reactivity

Human

Immunogen

A phospho specific peptide corresponding to residues surrounding S33 of human KRT18

Host

Rabbit

Applications

WB, IHC

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

46kDa

Formulation

Phospho-KRT18-S33 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

K18 antibody; CYK18 antibody;

Protein names

K18; CYK18;

Protein function

Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

Protein tissue specificity

Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.

Protein sequence and domain

Belongs to the intermediate filament family.

Protein post-translational modifications

Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.; Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7.; O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation.

Protein cellular localization

Cytoplasm, perinuclear region. Nucleus, nucleolus.

Background

KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Structural-Proteins/">Structural Proteins</a>><a href="http://antibodyplus.com/product-tag/Cytokeratin/">Cytokeratin</a><br><a href="http://antibodyplus.com/product-tag/Structural-Proteins/"&gt; (View all antibody categories related to Structural Proteins)</a>

Note

AntibodyPlus can customize Phospho-KRT18-S33 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below: