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Rabbit Polyclonal Phospho-KRT18-S33 antibody (AP0263)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:1000
IHC 1:50 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit Polyclonal Phospho-KRT18-S33 antibody.
Check alternative names for the antibodyExpand
K18 antibody; CYK18 antibody;
Cell proliferation inducing gene 46 protein antibody|Cell proliferation inducing protein 46 antibody|Cell proliferation-inducing gene 46 protein antibody|CK 18 antibody|CK-18 antibody|CK18 antibody|CYK 18 antibody|CYK18 antibody|Cytokeratin 18 antibody|Cytokeratin endo B antibody|Cytokeratin-18 antibody|K 18 antibody|K18 antibody|K1C18_HUMAN antibody|KA18 antibody|Keratin 18 antibody|Keratin 18, type I antibody|Keratin D antibody|keratin, type I cytoskeletal 18 antibody|Keratin-18 antibody|Krt18 antibody|Anti-Cytokeratin 18 antibody [C-04] (ab668)
SCBT cat No: sc-53254|sc-377224|sc-271937|sc-53255|sc-70915|sc-393091|sc-58726|sc-393002|sc-366511|sc-101461|sc-101931|sc-70917|sc-58727|sc-398871|sc-51582|sc-51583|sc-6259|sc-28264|sc-53256|sc-31700|sc-31701|sc-32722|
Rabbit Polyclonal Phospho-KRT18-S33 antibody
|Catalogue No.|| |
A phospho specific peptide corresponding to residues surrounding S33 of human KRT18
|Recommended dilution|| |
WB 1:500 – 1:1000<br/>IHC 1:50 – 1:100
|Molecular weight|| |
Phospho-KRT18-S33 antibody was tube-contained.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
K18 antibody; CYK18 antibody;
|Database links|| |
Human UniProt/Swiss-Prot:<a href="http://www.uniprot.org/uniprot/P05783">P05783</a>
|Protein names|| |
|Protein function|| |
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
|Protein tissue specificity|| |
Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
|Protein sequence and domain|| |
Belongs to the intermediate filament family.
|Protein post-translational modifications|| |
Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.; Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7.; O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation.
|Protein cellular localization|| |
Cytoplasm, perinuclear region. Nucleus, nucleolus.
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Structural-Proteins/">Structural Proteins</a>><a href="http://antibodyplus.com/product-tag/Cytokeratin/">Cytokeratin</a><br><a href="http://antibodyplus.com/product-tag/Structural-Proteins/"> (View all antibody categories related to Structural Proteins)</a>
AntibodyPlus can customize Phospho-KRT18-S33 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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