Rabbit Polyclonal Phospho-KRT8-S74 antibody (AP0386)


Reactivity: Human
Applications: WB,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-KRT8-S74 antibody (AP0386)

Supplier: ABclonal Inc.

Recommended applications: WB,IF

Recommended dilution:

WB 1:500 – 1:2000
IF 1:100 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit Polyclonal Phospho-KRT8-S74 antibody.

Alternative names:

Check alternative names for the antibody


K8 antibody; KO antibody; CK8 antibody; CK-8 antibody; CYK8 antibody; K2C8 antibody; CARD2 antibody;
CARD2 antibody|Cell proliferation inducing gene 46 protein antibody|Cell proliferation inducing protein 46 antibody|CK 8 antibody|CK-8 antibody|CK18 antibody|CK8 antibody|CYK18 antibody|CYK8 antibody|Cytokeratin 18 antibody|Cytokeratin 8 antibody|Cytokeratin-8 antibody|K18 antibody|K2C8 antibody|K2C8_HUMAN antibody|K8 antibody|Keratin 18 antibody|Keratin 8 antibody|Keratin antibody|Keratin type I cytoskeletal 18 antibody|keratin type II cytoskeletal 8 antibody|Keratin-8 antibody|KO antibody|KRT18 antibody|KRT8 antibody|type II cytoskeletal 8 antibody|Type-II keratin Kb8 antibody|Anti-Cytokeratin 8+18 antibody [EP1628Y] (ab53280)

SCBT cat No: sc-130312|sc-58736|sc-73480|sc-58737|sc-374275|sc-8020|sc-374274|sc-374027|sc-134484|sc-101459|sc-53266|sc-52324|


Rabbit Polyclonal Phospho-KRT8-S74 antibody

Catalogue No.





A phospho specific peptide corresponding to residues surrounding S74 of human KRT8











Molecular weight



Phospho-KRT8-S74 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.


Affinity purification


Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

K8 antibody; KO antibody; CK8 antibody; CK-8 antibody; CYK8 antibody; K2C8 antibody; CARD2 antibody;

Protein names

K8; KO; CK8; CK-8; CYK8; K2C8; CARD2;

Protein function

Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.

Protein tissue specificity

Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.

Protein sequence and domain

Belongs to the intermediate filament family.

Protein post-translational modifications

Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.; O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation.; O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.

Protein cellular localization

Cytoplasm . Nucleus, nucleoplasm . Nucleus matrix .


This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Structural-Proteins/">Structural Proteins</a>><a href="http://antibodyplus.com/product-tag/Cytokeratin/">Cytokeratin</a><br><a href="http://antibodyplus.com/product-tag/Structural-Proteins/"&gt; (View all antibody categories related to Structural Proteins)</a>


AntibodyPlus can customize Phospho-KRT8-S74 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody


ABclonal Inc.


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