Rabbit Polyclonal Phospho-LAT (Y191) antibody (STJ90819)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-LAT (Y191) antibody (STJ90819)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for LAT (phospho Tyr191) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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LAT antibody,|36 kDa phospho tyrosine adapter protein antibody|36 kDa phospho-tyrosine adapter protein antibody|36 kDa phospho-tyrosine adaptor protein antibody|LAT 1 antibody|lat antibody|LAT_HUMAN antibody|LAT1 antibody|Linker for activation of T cells antibody|Linker for activation of T cells family member 1 antibody|linker for activation of T cells, transmembrane adaptor antibody|Linker for activation of T-cells family member 1 antibody|p36 38 antibody|p36-38 antibody|pp36 antibody|Phospho anti-LAT (Y220) antibody [E225] (ab32434)
SCBT cat No: sc-31665|

 

Name

LAT (phospho Tyr191) Polyclonal Antibody

Catalogue No.

STJ90819

Reactivity

Human, Mouse, Rat

Specificity

Phospho-LAT (Y191) Polyclonal Antibody detects endogenous levels of LAT protein only when phosphorylated at Y191.

Immunogen

Synthesized phospho-peptide derived from LAT (phospho Tyr191) at AA range 160-240

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

28 kDa

Formulation

LAT (phospho Tyr191) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

LAT (phospho Tyr191) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Linker for activation of T-cells family member 1 antibody, 36 kDa phospho-tyrosine adapter protein antibody, pp36 antibody, p36-38 antibody

Database links

Human UniProt/Swiss-Prot:O43561;Mouse UniPort/Swiss-Prot: O54957;Rat UniProt/Swiss-Port: O70601;Human Entrez Gene: 27040;Mouse Entrez Gene: 16797;Rat Entrez Gene: Rn.9773

Protein names

Linker for activation of T-cells family member 1 , 36 kDa phospho-tyrosine adapter protein , pp36 , p36-38

Protein function

Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Protein tissue specificity

Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).

Protein post-translational modifications

Phosphorylated on tyrosines by ZAP70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ. Phosphorylated by ITK leading to the recruitment of VAV1 to LAT-containing complexes. / Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation.

Protein cellular localization

Cell membrane / Single-pass type III membrane protein

Research area

All research areas>Lymphocyte Signaling>LAT
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize LAT (phospho Tyr191) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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