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Rabbit Polyclonal Phospho-LAT (Y200) antibody (STJ90487)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for LAT (phospho Tyr200) Polyclonal Antibody.
Check alternative names for the antibodyExpand
LAT antibody,|36 kDa phospho tyrosine adapter protein antibody|36 kDa phospho-tyrosine adapter protein antibody|36 kDa phospho-tyrosine adaptor protein antibody|LAT 1 antibody|lat antibody|LAT_HUMAN antibody|LAT1 antibody|Linker for activation of T cells antibody|Linker for activation of T cells family member 1 antibody|linker for activation of T cells, transmembrane adaptor antibody|Linker for activation of T-cells family member 1 antibody|p36 38 antibody|p36-38 antibody|pp36 antibody|Phospho anti-LAT (Y220) antibody [E225] (ab32434)
SCBT cat No: sc-31665|
LAT (phospho Tyr200) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-LAT (Y200) Polyclonal Antibody detects endogenous levels of LAT protein only when phosphorylated at Y200.
Synthesized phospho-peptide derived from LAT (phospho Tyr200) at AA range 140-220
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000;
|Molecular weight|| |
LAT (phospho Tyr200) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
LAT (phospho Tyr200) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Linker for activation of T-cells family member 1 antibody, 36 kDa phospho-tyrosine adapter protein antibody, pp36 antibody, p36-38 antibody
|Protein names|| |
Linker for activation of T-cells family member 1 , 36 kDa phospho-tyrosine adapter protein , pp36 , p36-38
|Protein function|| |
Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
|Protein tissue specificity|| |
Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).
|Protein post-translational modifications|| |
Phosphorylated on tyrosines by ZAP70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ. Phosphorylated by ITK leading to the recruitment of VAV1 to LAT-containing complexes. / Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation.
|Protein cellular localization|| |
Cell membrane / Single-pass type III membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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