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Rabbit Polyclonal Phospho-LEF-1 (S42) antibody (STJ90534)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for LEF-1 (phospho Ser42) Polyclonal Antibody.
Check alternative names for the antibodyExpand
LEF1 antibody,|DKFZp586H0919 antibody|FLJ46390 antibody|LEF 1 antibody|LEF-1 antibody|Lef1 antibody|LEF1_HUMAN antibody|Lymphoid enhancer binding factor 1 antibody|Lymphoid enhancer-binding factor 1 antibody|T cell specific transcription factor 1 alpha antibody|T cell-specific transcription factor 1-alpha antibody|TCF 1 alpha antibody|TCF1 alpha antibody|TCF1-alpha antibody|TCF10 antibody|TCF1alpha antibody|TCF7L3 antibody|Transcription factor T cell specific 1 alpha antibody|Anti-LEF1 antibody [EP2030Y] (ab53293)
SCBT cat No: sc-81470|sc-374412|sc-374522|sc-8592|sc-28687|sc-8591|sc-56722|
LEF-1 (phospho Ser42) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-LEF-1 (S42) Polyclonal Antibody detects endogenous levels of LEF-1 protein only when phosphorylated at S42.
Synthesized phospho-peptide derived from LEF-1 (phospho Ser42) at AA range 20-100
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:5000;
|Molecular weight|| |
LEF-1 (phospho Ser42) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
LEF-1 (phospho Ser42) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Lymphoid enhancer-binding factor 1 antibody, LEF-1 antibody, T cell-specific transcription factor 1-alpha antibody, TCF1-alpha antibody
|Protein names|| |
Lymphoid enhancer-binding factor 1 , LEF-1 , T cell-specific transcription factor 1-alpha , TCF1-alpha
|Protein function|| |
Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.
|Protein tissue specificity|| |
Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines. Expressed in several pancreatic tumors and weakly expressed in normal pancreatic tissue. Isoforms 1 and 5 are detected in several pancreatic cell lines.
|Protein sequence and domain|| |
Proline-rich and acidic regions are implicated in the activation functions of RNA polymerase II transcription factors. / Belongs to the TCF/LEF family. / Contains 1 HMG box DNA-binding domain.
|Protein post-translational modifications|| |
Phosphorylated at Thr-155 and/or Ser-166 by NLK. Phosphorylation by NLK at these sites represses LEF1-mediated transcriptional activation of target genes of the canonical Wnt signaling pathway.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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