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Rabbit Polyclonal Phospho-Lfc (S885) antibody (STJ90558)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for Lfc (phospho Ser885) Polyclonal Antibody.
Check alternative names for the antibodyExpand
ARHGEF2 antibody, KIAA0651 antibody, LFP40 antibody,|AA408978 antibody|ARHG2 antibody|ARHG2_HUMAN antibody|ARHGEF 2 antibody|ARHGEF-2 antibody|ARHGEF2 antibody|GEF antibody|GEF H1 antibody|GEF-H1 antibody|GEFH1 antibody|Guanine nucleotide exchange factor H1 antibody|KIAA0651 antibody|Lbcl1 antibody|Lfc antibody|LFP40 antibody|MGC95068 antibody|Microtubule-regulated Rho-GEF antibody|mKIAA0651 antibody|P40 antibody|Proliferating cell nucleolar antigen p40 antibody|Protein GEF-H1 antibody|Rho guanine nucleotide exchange factor 2 antibody|rho/rac guanine nucleotide exchange factor (GEF) 2 antibody|rho/rac guanine nucleotide exchange factor 2 antibody|rho/rac guanine nucleotide exchange factor antibody|Anti-GEF H1 antibody (ab155785)
SCBT cat No: sc-134827|sc-49684|
Lfc (phospho Ser885) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-Lfc (S885) Polyclonal Antibody detects endogenous levels of Lfc protein only when phosphorylated at S885.
Synthesized phospho-peptide derived from Lfc (phospho Ser885) at AA range 820-900
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
|Molecular weight|| |
Lfc (phospho Ser885) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Lfc (phospho Ser885) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Rho guanine nucleotide exchange factor 2 antibody, Guanine nucleotide exchange factor H1 antibody, GEF-H1 antibody, Microtubule-regulated Rho-GEF antibody, Proliferating cell nucleolar antigen p40 antibody
|Protein names|| |
Rho guanine nucleotide exchange factor 2 , Guanine nucleotide exchange factor H1 , GEF-H1 , Microtubule-regulated Rho-GEF , Proliferating cell nucleolar antigen p40
|Protein function|| |
Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2.
|Protein tissue specificity|| |
Up-regulated by bacterial peptidoglycans stimulation, such as muramyl dipeptide and in biopsies from inflamed mucosal areas of Crohn’s disease patients.
|Protein sequence and domain|| |
The DH (DBL-homology) domain interacts with and promotes loading of GTP on RhoA. Promotes tyrosine phosphorylation of RIPK2. / The PH (pleckstrin-homology) domain is involved in microtubule binding and targeting to tight junctions. / Contains 1 DH (DBL-homology) domain. / Contains 1 PH domain. / Contains 1 phorbol-ester/DAG-type zinc finger.
|Protein post-translational modifications|| |
Phosphorylation of Ser-886 by PAK1 induces binding to protein YWHAZ, promoting its relocation to microtubules and the inhibition of its activity. Phosphorylated by AURKA and CDK1 during mitosis, which negatively regulates its activity. Phosphorylation by MAPK1 or MAPK3 increases nucleotide exchange activity. Phosphorylation by PAK4 releases GEF-H1 from the microtubules. Phosphorylated on serine, threonine and tyrosine residues in a RIPK2-dependent manner.
|Protein cellular localization|| |
Cytoplasm / Cell junction > tight junction / Golgi apparatus / Cytoplasm > cytoskeleton > spindle / Cell projection > ruffle membrane / Cytoplasmic vesicle
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St John’s Laboratory Ltd.
|Product type|| |
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