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Rabbit Polyclonal Phospho-MAK (Y159) antibody (STJ90583)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:40000;
Recommended protocols: check protocols
Click or hover above images to see image description for MAK (phospho Tyr159) Polyclonal Antibody.
Check alternative names for the antibodyExpand
MAK antibody,|intestinal cell kinase antibody|dJ417M14.2 antibody|fj04c02 antibody|Ick antibody|Mak antibody|MAK_HUMAN antibody|Male germ cell associated kinase antibody|Male germ cell-associated kinase antibody|male germ cell-associated kinase retinal-enriched isoform antibody|OTTHUMP00000016025 antibody|Rck antibody|RP62 antibody|Serine/threonine protein kinase MAK antibody|Serine/threonine-protein kinase MAK antibody|testicular secretory protein Li 28 antibody|wu:fj04c02 antibody|zgc:56603 antibody|Anti-MAK antibody (ab80536)
SCBT cat No: To be updated
MAK (phospho Tyr159) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-MAK (Y159) Polyclonal Antibody detects endogenous levels of MAK protein only when phosphorylated at Y159.
Synthesized phospho-peptide derived from MAK (phospho Tyr159) at AA range 100-180
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:40000;
|Molecular weight|| |
MAK (phospho Tyr159) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
MAK (phospho Tyr159) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Serine/threonine-protein kinase MAK antibody, Male germ cell-associated kinase antibody
|Protein names|| |
Serine/threonine-protein kinase MAK , Male germ cell-associated kinase
|Protein function|| |
Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells. / ATP + a protein = ADP + a phosphoprotein.
|Protein tissue specificity|| |
Expressed in prostate cancer cell lines at generally higher levels than in normal prostate epithelial cell lines. Isoform 1 is expressed in kidney, testis, lung, trachea, and retina. Isoform 2 is retina-specific where it is expressed in rod and cone photoreceptors.
|Involvement in disease|| |
Retinitis pigmentosa 62 (RP62) [MIM:614181]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. / Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Autophosphorylated. Phosphorylated on serine and threonine residues.
|Protein cellular localization|| |
Nucleus / Cytoplasm > cytoskeleton > microtubule organizing center > centrosome / Cytoplasm > cytoskeleton > spindle / Midbody / Cell projection > cilium > photoreceptor outer segment / Photoreceptor inner segment
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St John’s Laboratory Ltd.
|Product type|| |
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