Rabbit Polyclonal Phospho-MAP2K3-S189 antibody (AP0389)

$99.00$259.00

Reactivity: Human,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-MAP2K3-S189 antibody (AP0389)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000
IHC 1:50 – 1:100
IF 1:100 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

MEK3 antibody; MKK3 antibody; MAPKK3 antibody; PRKMK3 antibody; SAPKK2 antibody; SAPKK-2 antibody;
Dual specificity mitogen activated protein kinase kinase 6 antibody|Dual specificity mitogen-activated protein kinase kinase 3 antibody|MAP kinase kinase 3 antibody|MAP kinase kinase 6 antibody|map2k3 antibody|MAP2K6 antibody|MAPK/ERK kinase 3 antibody|MAPK/ERK kinase 6 antibody|MAPKK 3 antibody|MAPKK 6 antibody|MAPKK3 antibody|MAPKK6 antibody|MEK 3 antibody|MEK 6 antibody|Mitogen activated protein kinase kinase 3 antibody|Mitogen activated protein kinase kinase 6 antibody|MKK3 antibody|MKK6 antibody|MP2K3_HUMAN antibody|PRKMK3 antibody|PRKMK6 antibody|Protein kinase, mitogen activated, kinase 6 (MAP kinase kinase 6) antibody|SAPK kinase 2 antibody|SAPKK 3 antibody|SAPKK-2 antibody|SAPKK2 antibody|SAPKK3 antibody|Stress activated protein kinase kinase 3 antibody|Stress-activated protein kinase kinase 2 antibody|Anti-MEK3 + MEK6 antibody [EPR17340] (ab200831)

SCBT cat No: sc-166746|sc-166727|sc-166728|sc-1991|sc-1992|sc-136337|

Name

Rabbit Polyclonal Phospho-MAP2K3-S189 antibody

Catalogue No.

AP0389

Reactivity

Human, Rat

Immunogen

A phospho specific peptide corresponding to residues surrounding S189 of human MAP2K3

Host

Rabbit

Applications

WB, IHC, IF

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

40kDa

Formulation

Phospho-MAP2K3-S189 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MEK3 antibody; MKK3 antibody; MAPKK3 antibody; PRKMK3 antibody; SAPKK2 antibody; SAPKK-2 antibody;

Protein names

MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2;

Protein function

Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.

Protein tissue specificity

Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.

Protein sequence and domain

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.; Contains 1 protein kinase domain.

Protein post-translational modifications

Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity (PubMed:8622669). Phosphorylated by TAOK2 (PubMed:11279118).; Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.

Background

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Kinases-and-Phosphatases/">Kinases and Phosphatases</a>><a href="http://antibodyplus.com/product-tag/MEK/">MEK</a><br><a href="http://antibodyplus.com/product-tag/Kinases-and-Phosphatases/"&gt; (View all antibody categories related to Kinases and Phosphatases)</a>

Note

AntibodyPlus can customize Phospho-MAP2K3-S189 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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