Rabbit Polyclonal Phospho-MAPK9/MAPK10-T183 antibody (AP0395)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-MAPK9/MAPK10-T183 antibody (AP0395)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:1000
IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit Polyclonal Phospho-MAPK9/MAPK10-T183 antibody.

Alternative names:

Check alternative names for the antibody

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JNK2 antibody;
C Jun kinase 2 antibody|c Jun N terminal kinase 1 antibody|c Jun N terminal kinase 2 antibody|c Jun N terminal kinase 3 antibody|c-Jun N-terminal kinase 1 antibody|JNK 46 antibody|JNK 55 antibody|JNK antibody|JNK-46 antibody|JNK1 antibody|JNK1A2 antibody|JNK2 antibody|JNK21B1/2 antibody|JNK2A antibody|JNK2ALPHA antibody|JNK2B antibody|JNK2BETA antibody|JNK3 alpha protein kinase antibody|JNK3 antibody|JNK3A antibody|Jun kinase antibody|JUN N terminal kinase antibody|MAP kinase 10 antibody|MAP kinase 8 antibody|MAP kinase 9 antibody|MAP kinase p49 3F12 antibody|MAPK 10 antibody|MAPK 8 antibody|MAPK 9 antibody|MAPK10 antibody|mapk8 antibody|MAPK9 antibody|Mitogen activated protein kinase 10 antibody|Mitogen activated protein kinase 8 antibody|Mitogen activated protein kinase 8 isoform JNK1 alpha1 antibody|Mitogen activated protein kinase 8 isoform JNK1 beta2 antibody|Mitogen activated protein kinase 9 antibody|Mitogen-activated protein kinase 8 antibody|MK08_HUMAN antibody|p493F12 antibody|p54a antibody|p54aSAPK antibody|p54bSAPK antibody|PRKM10 antibody|PRKM8 antibody|PRKM9 antibody|SAPK antibody|SAPK(beta) antibody|SAPK1 antibody|SAPK1a antibody|SAPK1b antibody|SAPK1c antibody|Stress activated protein kinase 1 antibody|Stress activated protein kinase 1a antibody|Stress activated protein kinase 1b antibody|Stress activated protein kinase 1c antibody|Stress activated protein kinase beta antibody|Stress activated protein kinase JNK1 antibody|Stress activated protein kinase JNK2 antibody|Stress activated protein kinase JNK3 antibody|Stress-activated protein kinase 1c antibody|Stress-activated protein kinase JNK1 antibody|Anti-JNK2 antibody [EP1595Y] (ab76125)

SCBT cat No: sc-7345|sc-1648|

Name

Rabbit Polyclonal Phospho-MAPK9/MAPK10-T183 antibody

Catalogue No.

AP0395

Reactivity

Human, Mouse, Rat

Immunogen

A phospho specific peptide corresponding to residues surrounding T183 of human MAPK9/MAPK10

Host

Rabbit

Applications

WB, IHC

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

46/54kDa

Formulation

Phospho-MAPK9/MAPK10-T183 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

JNK2 antibody;

Protein names

JNK2;

Protein function

Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692).; MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.

Protein sequence and domain

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.; Contains 1 protein kinase domain. The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Protein post-translational modifications

Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Autophosphorylated in vitro.

Protein cellular localization

Cytoplasm . Nucleus .

Background

Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Kinases-and-Phosphatases/">Kinases and Phosphatases</a>><a href="http://antibodyplus.com/product-tag/JNK/">JNK</a><br><a href="http://antibodyplus.com/product-tag/Kinases-and-Phosphatases/"&gt; (View all antibody categories related to Kinases and Phosphatases)</a>

Note

AntibodyPlus can customize Phospho-MAPK9/MAPK10-T183 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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