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Rabbit Polyclonal Phospho-MAPKAPK2-T334 antibody (AP0396)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000
IHC 1:50 – 1:100
IF 1:100 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit Polyclonal Phospho-MAPKAPK2-T334 antibody.
Check alternative names for the antibodyExpand
MK2 antibody; MK-2 antibody; MAPKAP-K2 antibody;
MAP kinase activated protein Kinase 2 antibody|MAP kinase-activated protein kinase 2 antibody|MAPK activated protein kinase 2 antibody|MAPK-activated protein kinase 2 antibody|MAPK2_HUMAN antibody|MAPKAP K2 antibody|MAPKAP kinase 2 antibody|MAPKAPK 2 antibody|MAPKAPK-2 antibody|MAPKAPK2 antibody|Mitogen activated protein kinase activated protein kinase 2 antibody|MK 2 antibody|MK2 antibody|Phospho anti-MAPKAP Kinase 2 (T334) antibody (ab63378)
SCBT cat No: sc-100393|sc-393609|sc-6221|sc-7871|sc-514754|sc-164966|sc-104369|sc-100510|
Rabbit Polyclonal Phospho-MAPKAPK2-T334 antibody
|Catalogue No.|| |
Human, Mouse, Rat
A phospho specific peptide corresponding to residues surrounding T334 of human MAPKAPK2
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000<br/>IHC 1:50 – 1:100<br/>IF 1:100 – 1:200
|Molecular weight|| |
Phospho-MAPKAPK2-T334 antibody was tube-contained.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
MK2 antibody; MK-2 antibody; MAPKAP-K2 antibody;
|Database links|| |
Human UniProt/Swiss-Prot:<a href="http://www.uniprot.org/uniprot/P49137">P49137</a>
|Protein names|| |
MK2; MK-2; MAPKAP-K2;
|Protein function|| |
Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSF1, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to the regulation of the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity, leading to inhibition of dependent degradation of ARE-containing transcripts. Phosphorylates CEP131 in response to cellular stress induced by ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites (PubMed:26616734). Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.
|Protein tissue specificity|| |
Expressed in all tissues examined.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.; Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Sumoylation inhibits the protein kinase activity.; Phosphorylated and activated by MAP kinase p38-alpha/MAPK14 at Thr-222, Ser-272 and Thr-334.
|Protein cellular localization|| |
Cytoplasm . Nucleus . Note=Phosphorylation and subsequent activation releases the autoinhibitory helix, resulting in the export from the nucleus into the cytoplasm.
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.
AntibodyPlus can customize Phospho-MAPKAPK2-T334 antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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