Rabbit polyclonal Phospho-MAX-S11 antibody (AP0072)

$69.00$259.00

Reactivity: Human
Applications: WB,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal Phospho-MAX-S11 antibody (AP0072)

Supplier: ABclonal Inc.

Recommended applications: WB,IF

Recommended dilution:

WB 1:500 – 1:2000 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal Phospho-MAX-S11 antibody.

Alternative names:

Check alternative names for the antibody

Expand

MGC10775 antibody, MGC11225 antibody, MGC18164 antibody, MGC34679 antibody, MGC36767 antibody,bHLHd4 antibody, bHLHd5 antibody, bHLHd6 antibody, bHLHd7 antibody, bHLHd8 antibody, orf1 antibody
bHLHd4 antibody|bHLHd5 antibody|bHLHd6 antibody|bHLHd7 antibody|bHLHd8 antibody|Helix loop helix zipper protein antibody|MAX protein antibody|MGC10775 antibody|MGC11225 antibody|MGC18164 antibody|MGC34679 antibody|MGC36767 antibody|MYC associated factor X antibody|Myc binding novel HLH/LZ protein antibody|Orf 1 antibody|Orf1 antibody|Protein max antibody|Anti-MAX antibody [73C5a] – ChIP Grade (ab53570)

SCBT cat No: sc-765|sc-197|sc-8011|sc-374142|

Name

Rabbit polyclonal Phospho-MAX-S11 antibody

Catalogue No.

AP0072

Reactivity

Human

Immunogen

A phospho specific peptide corresponding to residues surrounding S11 of human MAX

Host

Rabbit

Applications

WB, IF

Recommended dilution

WB 1:500 – 1:2000
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: /Observed: Refer to Figures

Formulation

Phospho-MAX-S11 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Phospho-MAX-S11 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MGC10775 antibody, MGC11225 antibody, MGC18164 antibody, MGC34679 antibody, MGC36767 antibody,bHLHd4 antibody, bHLHd5 antibody, bHLHd6 antibody, bHLHd7 antibody, bHLHd8 antibody, orf1 antibody

Database links

Human UniProt/Swiss-Prot:P61244

Protein names

MGC10775, MGC11225, MGC18164, MGC34679, MGC36767,bHLHd4, bHLHd5, bHLHd6, bHLHd7, bHLHd8, orf1

Protein function

Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5′-CAC[GA]TG-3′. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 ‘Lys-9’ histone methyltransferase activity.

Protein tissue specificity

High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.

Protein sequence and domain

Belongs to the MAX family.; Contains 1 bHLH (basic helix-loop-helix) domain.

Protein post-translational modifications

Reversible lysine acetylation might regulate the nuclear-cytoplasmic shuttling of specific Max complexes.

Protein cellular localization

Nucleus. Cell projection, dendrite .

Background

Members of the Myc/Max/Mad network function as transcriptional regulators with roles in various aspects of cell behavior including proliferation, differentiation and apoptosis (1). These proteins share a common basic-helix-loop-helix leucine zipper (bHLH-ZIP) motif required for dimerization and DNA-binding. Max was originally discovered based on its ability to associate with c-Myc and found to be required for the ability of Myc to bind DNA and activate transcription (2). Subsequently, Max has been viewed as a central component of the transcriptional network, forming homodimers as well as heterodimers with other members of the Myc and Mad families (1). The association between Max and either Myc or Mad can have opposing effects on transcriptional regulation and cell behavior (1). The Mad family consists of four related proteins; Mad1, Mad2 (Mxi1), Mad3 and Mad4, and the more distantly related members of the bHLH-ZIP family, Mnt and Mga. Like Myc, the Mad proteins are tightly regulated with short half-lives. In general, Mad family members interfere with Myc-mediated processes such as proliferation, transformation and prevention of apoptosis by inhibiting transcription (3,4).

Research area

All research areas>Transcription Regulators>Max
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize Phospho-MAX-S11 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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