Rabbit Polyclonal Phospho-MEF-2C (S396) antibody (STJ90982)

$99.00$319.00

Reactivity: Human, Mouse
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-MEF-2C (S396) antibody (STJ90982)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for MEF-2C (phospho Ser396) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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MEF2C antibody,|C5DELq14.3 antibody|DEL5q14.3 antibody|MADS box transcription enhancer factor 2 polypeptide C (myocyte enhancer factor 2C) antibody|MADS box transcription enhancer factor 2, polypeptide C antibody|MEF2C antibody|MEF2C_HUMAN antibody|Myocyte enhancer factor 2C antibody|Myocyte specific enhancer factor 2C antibody|Myocyte-specific enhancer factor 2C antibody|OTTHUMP00000222409 antibody|Similar to MADS box transcription enhancer factor 2 polypeptide C antibody|Anti-MEF2C [EPR1452(N)] antibody (ab191428)
SCBT cat No: sc-13268|sc-13266|sc-365862|sc-136196|sc-13922|sc-271153|

 

Name

MEF-2C (phospho Ser396) Polyclonal Antibody

Catalogue No.

STJ90982

Reactivity

Human, Mouse

Specificity

Phospho-MEF-2C (S396) Polyclonal Antibody detects endogenous levels of MEF-2C protein only when phosphorylated at S396.

Immunogen

Synthesized phospho-peptide derived from MEF-2C (phospho Ser396) at AA range 340-420

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

51 kDa

Formulation

MEF-2C (phospho Ser396) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

MEF-2C (phospho Ser396) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Myocyte-specific enhancer factor 2C antibody

Database links

Human UniProt/Swiss-Prot:Q06413;Mouse UniPort/Swiss-Prot: Q8CFN5;Rat UniProt/Swiss-Port: A0A096MJY4;Human Entrez Gene: 4208;Mouse Entrez Gene: 17260;

Protein names

Myocyte-specific enhancer factor 2C

Protein function

Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

Protein tissue specificity

Expressed in brain and skeletal muscle.

Involvement in disease

Mental retardation, autosomal dominant 20 (MRD20) [MIM:613443]: A disorder characterized by severe mental retardation, absent speech, hypotonia, poor eye contact and stereotypic movements. Dysmorphic features include high broad forehead with variable small chin, short nose with anteverted nares, large open mouth, upslanted palpebral fissures and prominent eyebrows. Some patients have seizures. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

The beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activity. / Belongs to the MEF2 family. / Contains 1 MADS-box domain. / Contains 1 Mef2-type DNA-binding domain.

Protein post-translational modifications

Phosphorylation on Ser-59 enhances DNA binding activity (By similarity). Phosphorylation on Ser-396 is required for Lys-391 sumoylation and inhibits transcriptional activity. / Acetylated by p300 on several sites in diffentiating myocytes. Acetylation on Lys-4 increases DNA binding and transactivation (By similarity). / Sumoylated on Lys-391 with SUMO2 but not by SUMO1 represses transcriptional activity. / Proteolytically cleaved in cerebellar granule neurons, probably by caspase 7, following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation.

Protein cellular localization

Nucleus

Research area

All research areas>Transcription Regulators>MEF
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize MEF-2C (phospho Ser396) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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