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Rabbit Polyclonal Phospho-MEF-2C (S396) antibody (STJ90982)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for MEF-2C (phospho Ser396) Polyclonal Antibody.
Check alternative names for the antibodyExpand
MEF2C antibody,|C5DELq14.3 antibody|DEL5q14.3 antibody|MADS box transcription enhancer factor 2 polypeptide C (myocyte enhancer factor 2C) antibody|MADS box transcription enhancer factor 2, polypeptide C antibody|MEF2C antibody|MEF2C_HUMAN antibody|Myocyte enhancer factor 2C antibody|Myocyte specific enhancer factor 2C antibody|Myocyte-specific enhancer factor 2C antibody|OTTHUMP00000222409 antibody|Similar to MADS box transcription enhancer factor 2 polypeptide C antibody|Anti-MEF2C [EPR1452(N)] antibody (ab191428)
SCBT cat No: sc-13268|sc-13266|sc-365862|sc-136196|sc-13922|sc-271153|
MEF-2C (phospho Ser396) Polyclonal Antibody
|Catalogue No.|| |
Phospho-MEF-2C (S396) Polyclonal Antibody detects endogenous levels of MEF-2C protein only when phosphorylated at S396.
Synthesized phospho-peptide derived from MEF-2C (phospho Ser396) at AA range 340-420
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
|Molecular weight|| |
MEF-2C (phospho Ser396) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
MEF-2C (phospho Ser396) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Myocyte-specific enhancer factor 2C antibody
|Protein names|| |
Myocyte-specific enhancer factor 2C
|Protein function|| |
Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
|Protein tissue specificity|| |
Expressed in brain and skeletal muscle.
|Involvement in disease|| |
Mental retardation, autosomal dominant 20 (MRD20) [MIM:613443]: A disorder characterized by severe mental retardation, absent speech, hypotonia, poor eye contact and stereotypic movements. Dysmorphic features include high broad forehead with variable small chin, short nose with anteverted nares, large open mouth, upslanted palpebral fissures and prominent eyebrows. Some patients have seizures. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activity. / Belongs to the MEF2 family. / Contains 1 MADS-box domain. / Contains 1 Mef2-type DNA-binding domain.
|Protein post-translational modifications|| |
Phosphorylation on Ser-59 enhances DNA binding activity (By similarity). Phosphorylation on Ser-396 is required for Lys-391 sumoylation and inhibits transcriptional activity. / Acetylated by p300 on several sites in diffentiating myocytes. Acetylation on Lys-4 increases DNA binding and transactivation (By similarity). / Sumoylated on Lys-391 with SUMO2 but not by SUMO1 represses transcriptional activity. / Proteolytically cleaved in cerebellar granule neurons, probably by caspase 7, following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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