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Rabbit polyclonal Phospho-MEF2C-S396 antibody (AP0075)
Supplier: ABclonal Inc.
Recommended applications: WB,IF
WB 1:500 – 1:2000 IF 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal Phospho-MEF2C-S396 antibody.
Check alternative names for the antibodyExpand
DEL5q14.3 antibody, C5DELq14.3 antibody
C5DELq14.3 antibody|DEL5q14.3 antibody|MADS box transcription enhancer factor 2 polypeptide C (myocyte enhancer factor 2C) antibody|MADS box transcription enhancer factor 2, polypeptide C antibody|MEF2C antibody|MEF2C_HUMAN antibody|Myocyte enhancer factor 2C antibody|Myocyte specific enhancer factor 2C antibody|Myocyte-specific enhancer factor 2C antibody|OTTHUMP00000222409 antibody|Similar to MADS box transcription enhancer factor 2 polypeptide C antibody|Anti-MEF2C [EPR1452(N)] antibody (ab191428)
SCBT cat No: sc-13268|sc-13266|sc-365862|sc-136196|sc-13922|sc-271153|
Rabbit polyclonal Phospho-MEF2C-S396 antibody
|Catalogue No.|| |
A phospho specific peptide corresponding to residues surrounding S396 of human MEF2C
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 51kDa/Observed: Refer to Figures
Phospho-MEF2C-S396 antibody was tube-contained.
Phospho-MEF2C-S396 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
DEL5q14.3 antibody, C5DELq14.3 antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
|Protein tissue specificity|| |
Expressed in brain and skeletal muscle.
|Protein sequence and domain|| |
The beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activity.Belongs to the MEF2 family.; Contains 1 MADS-box domain.; Contains 1 Mef2-type DNA-binding domain.
|Protein post-translational modifications|| |
Phosphorylation on Ser-59 enhances DNA binding activity (By similarity). Phosphorylation on Ser-396 is required for Lys-391 sumoylation and inhibits transcriptional activity.; Acetylated by p300 on several sites in diffentiating myocytes. Acetylation on Lys-4 increases DNA binding and transactivation (By similarity).; Sumoylated on Lys-391 with SUMO2 but not by SUMO1 represses transcriptional activity.; Proteolytically cleaved in cerebellar granule neurons, probably by caspase 7, following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation.
|Protein cellular localization|| |
This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe mental retardation, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described.
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|Product type|| |
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