Rabbit Polyclonal Phospho-MEK-2 (T394) antibody (STJ90329)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, IHC, IP, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-MEK-2 (T394) antibody (STJ90329)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IP, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IP 1:200-500; ELISA 1:10000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for MEK-2 (phospho Thr394) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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MAP2K2 antibody, MEK2 antibody, MKK2 antibody, PRKMK2 antibody,|Cardiofaciocutaneous syndrome antibody|CFC syndrome antibody|CFC4 antibody|Dual specificity mitogen activated protein kinase kinase 2 antibody|Dual specificity mitogen-activated protein kinase kinase 2 antibody|ERK activator kinase 2 antibody|FLJ26075 antibody|MAP kinase kinase 2 antibody|map2k2 antibody|MAPK / ERK kinase 2 antibody|MAPK/ERK kinase 2 antibody|MAPKK 2 antibody|MAPKK2 antibody|MEK 2 antibody|MEK2 antibody|Microtubule associated protein kinase kinase 2 antibody|Mitogen activated protein kinase kinase 2 antibody|Mitogen activated protein kinase kinase 2 p45 antibody|MKK 2 antibody|MKK2 antibody|MP2K2_HUMAN antibody|OTTHUMP00000165826 antibody|OTTHUMP00000165827 antibody|PRKMK 2 antibody|PRKMK2 antibody|Anti-MEK2 antibody [Y78] (ab32517)
SCBT cat No: sc-81473|sc-136261|sc-13159|sc-525|sc-524|sc-135985|sc-81474|

 

Name

MEK-2 (phospho Thr394) Polyclonal Antibody

Catalogue No.

STJ90329

Reactivity

Human, Mouse, Rat

Specificity

Phospho-MEK-2 (T394) Polyclonal Antibody detects endogenous levels of MEK-2 protein only when phosphorylated at T394.

Immunogen

Synthesized phospho-peptide derived from MEK-2 (phospho Thr394) at AA range 340-420

Host

Rabbit

Applications

WB, IHC, IP, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; IP 1:200-500; ELISA 1:10000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

45 kDa

Formulation

MEK-2 (phospho Thr394) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

MEK-2 (phospho Thr394) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Dual specificity mitogen-activated protein kinase kinase 2 antibody, MAP kinase kinase 2 antibody, MAPKK 2 antibody, ERK activator kinase 2 antibody, MAPK/ERK kinase 2 antibody, MEK 2 antibody

Database links

Human UniProt/Swiss-Prot:P36507;Mouse UniPort/Swiss-Prot: Q63932;Rat UniProt/Swiss-Port: P36506;Human Entrez Gene: 5606;Mouse Entrez Gene: 26396;Rat Entrez Gene: Rn.82693

Protein names

Dual specificity mitogen-activated protein kinase kinase 2 , MAP kinase kinase 2 , MAPKK 2 , ERK activator kinase 2 , MAPK/ERK kinase 2 , MEK 2

Protein function

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). / ATP + a protein = ADP + a phosphoprotein. / Mg2+

Involvement in disease

Cardiofaciocutaneous syndrome 4 (CFC4) [MIM:615280]: A form of cardiofaciocutaneous syndrome, a multiple congenital anomaly disorder characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. / Contains 1 protein kinase domain.

Protein post-translational modifications

MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1). Phosphorylated by MAP2K1/MEK1 (By similarity). / Acetylation of Ser-222 and Ser-226 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.

Protein cellular localization

Cytoplasm / Membrane / Peripheral membrane protein

Research area

All research areas>Kinases and Phosphatases>MEK
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize MEK-2 (phospho Thr394) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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