Rabbit Polyclonal Phospho-MEK-3 (T222) antibody (STJ90949)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-MEK-3 (T222) antibody (STJ90949)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for MEK-3 (phospho Thr222) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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MAP2K3 antibody, MEK3 antibody, MKK3 antibody, PRKMK3 antibody, SKK2 antibody,|Dual specificity mitogen activated protein kinase kinase 6 antibody|Dual specificity mitogen-activated protein kinase kinase 3 antibody|MAP kinase kinase 3 antibody|MAP kinase kinase 6 antibody|map2k3 antibody|MAP2K6 antibody|MAPK/ERK kinase 3 antibody|MAPK/ERK kinase 6 antibody|MAPKK 3 antibody|MAPKK 6 antibody|MAPKK3 antibody|MAPKK6 antibody|MEK 3 antibody|MEK 6 antibody|Mitogen activated protein kinase kinase 3 antibody|Mitogen activated protein kinase kinase 6 antibody|MKK3 antibody|MKK6 antibody|MP2K3_HUMAN antibody|PRKMK3 antibody|PRKMK6 antibody|Protein kinase, mitogen activated, kinase 6 (MAP kinase kinase 6) antibody|SAPK kinase 2 antibody|SAPKK 3 antibody|SAPKK-2 antibody|SAPKK2 antibody|SAPKK3 antibody|Stress activated protein kinase kinase 3 antibody|Stress-activated protein kinase kinase 2 antibody|Anti-MEK3 + MEK6 antibody [EPR17340] (ab200831)
SCBT cat No: sc-166746|sc-166727|sc-166728|sc-1991|sc-1992|sc-136337|

 

Name

MEK-3 (phospho Thr222) Polyclonal Antibody

Catalogue No.

STJ90949

Reactivity

Human, Mouse, Rat

Specificity

Phospho-MEK-3 (T222) Polyclonal Antibody detects endogenous levels of MEK-3 protein only when phosphorylated at T222.

Immunogen

Synthesized phospho-peptide derived from MEK-3 (phospho Thr222) at AA range 160-240

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

39 kDa

Formulation

MEK-3 (phospho Thr222) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

MEK-3 (phospho Thr222) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Dual specificity mitogen-activated protein kinase kinase 3 antibody, MAP kinase kinase 3 antibody, MAPKK 3 antibody, MAPK/ERK kinase 3 antibody, MEK 3 antibody, Stress-activated protein kinase kinase 2 antibody, SAPK kinase 2 antibody, SAPKK-2 antibody, SAPKK2 antibody

Database links

Human UniProt/Swiss-Prot:P46734;Mouse UniPort/Swiss-Prot: O09110;Rat UniProt/Swiss-Port: B1H230;Human Entrez Gene: 5606;Mouse Entrez Gene: 26397;Rat Entrez Gene: Rn.100064

Protein names

Dual specificity mitogen-activated protein kinase kinase 3 , MAP kinase kinase 3 , MAPKK 3 , MAPK/ERK kinase 3 , MEK 3 , Stress-activated protein kinase kinase 2 , SAPK kinase 2 , SAPKK-2 , SAPKK2

Protein function

Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. / ATP + a protein = ADP + a phosphoprotein. / Activated by dual phosphorylation on Ser-218 and Thr-222.

Protein tissue specificity

Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.

Involvement in disease

Note: Defects in MAP2K3 may be involved in colon cancer.

Protein sequence and domain

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. / Contains 1 protein kinase domain.

Protein post-translational modifications

Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity . Phosphorylated by TAOK2 . / Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.

Research area

All research areas>Kinases and Phosphatases>MEK
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize MEK-3 (phospho Thr222) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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