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Rabbit Polyclonal Phospho-MEK-6 (S207) antibody (STJ90333)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000;
Recommended protocols: check protocols
Click or hover above images to see image description for MEK-6 (phospho Ser207) Polyclonal Antibody.
Check alternative names for the antibodyExpand
MAP2K6 antibody, MEK6 antibody, MKK6 antibody, PRKMK6 antibody, SKK3 antibody,||
SCBT cat No: To be updated
MEK-6 (phospho Ser207) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-MEK-6 (S207) Polyclonal Antibody detects endogenous levels of MEK-6 protein only when phosphorylated at S207.
Synthesized phospho-peptide derived from human MEK-6 around the phosphorylation site of S207
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000;
|Molecular weight|| |
MEK-6 (phospho Ser207) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
MEK-6 (phospho Ser207) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Dual specificity mitogen-activated protein kinase kinase 6 antibody, MAP kinase kinase 6 antibody, MAPKK 6 antibody, MAPK/ERK kinase 6 antibody, MEK 6 antibody, Stress-activated protein kinase kinase 3 antibody, SAPK kinase 3 antibody, SAPKK-3 antibody, SAPKK3 antibody
|Protein names|| |
Dual specificity mitogen-activated protein kinase kinase 6 , MAP kinase kinase 6 , MAPKK 6 , MAPK/ERK kinase 6 , MEK 6 , Stress-activated protein kinase kinase 3 , SAPK kinase 3 , SAPKK-3 , SAPKK3
|Protein function|| |
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases. / ATP + a protein = ADP + a phosphoprotein. / Activated by dual phosphorylation on Ser-207 and Thr-211 in response to a variety of cellular stresses, including UV radiation, osmotic shock, hypoxia, inflammatory cytokines, interferon gamma (IFNG), and less often by growth factors. MAP2K6/MKK6 is activated by the majority of M3Ks, such as MAP3K5/ASK1, MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK3, MAP3K4/MEKK4, MAP3K7/TAK1, MAP3K11/MLK3 and MAP3K17/TAOK2.
|Protein tissue specificity|| |
Isoform 2 is only expressed in skeletal muscle. Isoform 1 is expressed in skeletal muscle, heart, and in lesser extent in liver or pancreas.
|Protein sequence and domain|| |
The DVD domain (residues 311-334) contains a conserved docking site and is found in the mammalian MAP kinase kinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are essential for activation. / The D domain (residues 4-19) contains a conserved docking site and is required for the binding to MAPK substrates. / Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. / Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Weakly autophosphorylated. Phosphorylated at Ser-207 and Thr-211 by the majority of M3Ks, such as MAP3K5/ASK1, MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK3, MAP3K4/MEKK4, MAP3K7/TAK1, MAP3K11/MLK3 and MAP3K17/TAOK2. / Acetylation of Ser-207 and Thr-211 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.
|Protein cellular localization|| |
Nucleus / Cytoplasm / Cytoplasm > cytoskeleton
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St John’s Laboratory Ltd.
|Product type|| |
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