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Rabbit Polyclonal Phospho-MEK-7 (T275) antibody (STJ90586)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
MAP2K7 antibody, JNKK2 antibody, MEK7 antibody, MKK7 antibody, PRKMK7 antibody, SKK4 antibody,|c-Jun N-terminal kinase kinase 2 antibody|Dual specificity mitogen activated protein kinase kinase 7 antibody|Dual specificity mitogen-activated protein kinase kinase 7 antibody|JNK activating kinase 2 antibody|JNK kinase 2 antibody|JNK-activating kinase 2 antibody|JNKK 2 antibody|Jnkk-2 antibody|Jnkk2 antibody|MAP kinase kinase 7 antibody|MAP2K7 antibody|MAPK/ERK kinase 7 antibody|MAPKK 7 antibody|MAPKK-7 antibody|MAPKK7 antibody|MEK 7 antibody|Mitogen Activated Protein Kinase kinase 7 antibody|MKK 7 antibody|MKK-7 antibody|MKK7 antibody|MP2K7_HUMAN antibody|PRKMK 7 antibody|PRKMK-7 antibody|PRKMK7 antibody|SAPK kinase 4 antibody|SAPKK-4 antibody|SAPKK4 antibody|Sek 2 antibody|Sek-2 antibody|Sek2 antibody|SKK4 antibody|stress-activated protein kinase kinase 4 antibody|Anti-MEK7 antibody [EP1455Y] (ab52618) KO Validated
SCBT cat No: sc-7103|sc-25288|sc-13071|sc-7104|
MEK-7 (phospho Thr275) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-MEK-7 (T275) Polyclonal Antibody detects endogenous levels of MEK-7 protein only when phosphorylated at T275.
Synthesized phospho-peptide derived from MEK-7 (phospho Thr275) at AA range 210-290
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;
|Molecular weight|| |
MEK-7 (phospho Thr275) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
MEK-7 (phospho Thr275) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Dual specificity mitogen-activated protein kinase kinase 7 antibody, MAP kinase kinase 7 antibody, MAPKK 7 antibody, JNK-activating kinase 2 antibody, MAPK/ERK kinase 7 antibody, MEK 7 antibody, Stress-activated protein kinase kinase 4 antibody, SAPK kinase 4 antibody, SAPKK-4 antibody, SAPKK4 antibody, c-Jun N-terminal kinase kinase 2 antibody, JNK kinase 2 antibody, JNKK 2 antibody
|Protein names|| |
Dual specificity mitogen-activated protein kinase kinase 7 , MAP kinase kinase 7 , MAPKK 7 , JNK-activating kinase 2 , MAPK/ERK kinase 7 , MEK 7 , Stress-activated protein kinase kinase 4 , SAPK kinase 4 , SAPKK-4 , SAPKK4 , c-Jun N-terminal kinase kinase 2 , JNK kinase 2 , JNKK 2
|Protein function|| |
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. / ATP + a protein = ADP + a phosphoprotein. / Mg2+ / Activated by phosphorylation by specific MAP kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3, MAP3K11/MLK3 and MAP3K12/DLK.
|Protein tissue specificity|| |
Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.
|Protein sequence and domain|| |
The DVD domain (residues 377-400) contains a conserved docking site and is found in the mammalian MAP kinase kinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are essential for activation. / The D domain (residues 37-57) contains a conserved docking site and is required for the binding to MAPK substrates. / Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. / Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Activated by phosphorylation on Ser-271 and Thr-275 by MAP kinase kinase kinases (MAP3Ks).
|Protein cellular localization|| |
Nucleus / Cytoplasm
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St John’s Laboratory Ltd.
|Product type|| |
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