Rabbit polyclonal Phospho-MEK1/2-S217/221 antibody (AP0483)


Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal Phospho-MEK1/2-S217/221 antibody (AP0483)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal Phospho-MEK1/2-S217/221 antibody.

Alternative names:

Check alternative names for the antibody


CFC3 antibody, MEK1 antibody, MKK1 antibody, MAPKK1 antibody, PRKMK1 antibody
Cardiofaciocutaneous syndrome antibody|CFC syndrome antibody|CFC4 antibody|Dual specificity mitogen activated protein kinase kinase 2 antibody|Dual specificity mitogen-activated protein kinase kinase 2 antibody|ERK activator kinase 2 antibody|FLJ26075 antibody|MAP kinase kinase 2 antibody|map2k2 antibody|MAPK / ERK kinase 2 antibody|MAPK/ERK kinase 2 antibody|MAPKK 2 antibody|MAPKK2 antibody|MEK 2 antibody|MEK2 antibody|Microtubule associated protein kinase kinase 2 antibody|Mitogen activated protein kinase kinase 2 antibody|Mitogen activated protein kinase kinase 2 p45 antibody|MKK 2 antibody|MKK2 antibody|MP2K2_HUMAN antibody|OTTHUMP00000165826 antibody|OTTHUMP00000165827 antibody|PRKMK 2 antibody|PRKMK2 antibody|Anti-MEK2 antibody [Y78] (ab32517)

SCBT cat No: sc-81473|sc-136261|sc-13159|sc-525|sc-524|sc-135985|sc-81474|


Rabbit polyclonal Phospho-MEK1/2-S217/221 antibody

Catalogue No.





A phospho specific peptide corresponding to residues surrounding S217/221 of human MEK1/2





Recommended dilution

WB 1:500 – 1:2000







Molecular weight

Predicted: 43kDa/Observed: Refer to figures


Phospho-MEK1/2-S217/221 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.


Phospho-MEK1/2-S217/221 antibody was purified using affinity purification.


Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CFC3 antibody, MEK1 antibody, MKK1 antibody, MAPKK1 antibody, PRKMK1 antibody

Database links

Human UniProt/Swiss-Prot:P36507

Protein names


Protein function

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).

Protein sequence and domain

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.; Contains 1 protein kinase domain.

Protein post-translational modifications

MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1). Phosphorylated by MAP2K1/MEK1 (By similarity).; Acetylation of Ser-222 and Ser-226 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.

Protein cellular localization

Cytoplasm . Membrane ; Peripheral membrane protein . Note: Membrane localization is probably regulated by its interaction with KSR1.


The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

Research area

All research areas>Kinases and Phosphatases>MEK
(View all antibody categories related to Kinases and Phosphatases)


AntibodyPlus can customize Phospho-MEK1/2-S217/221 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody


ABclonal Inc.


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