Rabbit Polyclonal Phospho-MET-Y1349 antibody (AP0230)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-MET-Y1349 antibody (AP0230)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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HGFR antibody; AUTS9 antibody; RCCP2 antibody; c-Met antibody;
AUTS9 antibody|c met antibody|D249 antibody|Hepatocyte growth factor receptor antibody|HGF antibody|HGF receptor antibody|HGF/SF receptor antibody|HGFR antibody|MET antibody|Met proto oncogene tyrosine kinase antibody|MET proto oncogene, receptor tyrosine kinase antibody|Met proto-oncogene (hepatocyte growth factor receptor) antibody|Met proto-oncogene antibody|Met protooncogene antibody|MET_HUMAN antibody|Oncogene MET antibody|Par4 antibody|Proto-oncogene c-Met antibody|RCCP2 antibody|Scatter factor receptor antibody|SF receptor antibody|Tyrosine-protein kinase Met antibody|Anti-Met (c-Met) antibody [EP1454Y] (ab51067)

SCBT cat No: sc-10|sc-161|sc-514148|sc-514149|sc-8307|sc-46394|sc-46395|sc-162|sc-47705|sc-12807|sc-293488|sc-164990|sc-168580|sc-514653|sc-376779|

Name

Rabbit Polyclonal Phospho-MET-Y1349 antibody

Catalogue No.

AP0230

Reactivity

Human, Mouse, Rat

Immunogen

A phospho specific peptide corresponding to residues surrounding Y1349 of human MET

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

156kDa

Formulation

Phospho-MET-Y1349 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HGFR antibody; AUTS9 antibody; RCCP2 antibody; c-Met antibody;

Protein names

HGFR; AUTS9; RCCP2; c-Met;

Protein function

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity).; Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.

Protein tissue specificity

Expressed in normal hepatocytes as well as in epithelial cells lining the stomach, the small and the large intestine. Found also in basal keratinocytes of esophagus and skin. High levels are found in liver, gastrointestinal tract, thyroid and kidney. Also present in the brain. Expressed in metaphyseal bone (at protein level) (PubMed:26637977).

Protein sequence and domain

Belongs to the protein kinase superfamily. Tyr protein kinase family.; Contains 3 IPT/TIG domains.; Contains 1 protein kinase domain.; Contains 1 Sema domain. The kinase domain is involved in SPSB1 binding.; The beta-propeller Sema domain mediates binding to HGF.

Protein post-translational modifications

Autophosphorylated in response to ligand binding on Tyr-1234 and Tyr-1235 in the kinase domain leading to further phosphorylation of Tyr-1349 and Tyr-1356 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1349 and Tyr-1365. Dephosphorylated by PTPN1 and PTPN2.; Ubiquitinated. Ubiquitination by CBL regulates MET endocytosis, resulting in decreasing plasma membrane receptor abundance, and in endosomal degradation and/or recycling of internalized receptors.

Protein cellular localization

Membrane; Single-pass type I membrane protein.; Isoform 3: Secreted.

Background

The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Membrane-Receptors/">Membrane Receptors</a>><a href="http://antibodyplus.com/product-tag/Met/">Met</a><br><a href="http://antibodyplus.com/product-tag/Membrane-Receptors/"&gt; (View all antibody categories related to Membrane Receptors)</a>

Note

AntibodyPlus can customize Phospho-MET-Y1349 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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