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Rabbit polyclonal Phospho-MKNK1-T197/202 antibody (AP0544)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:500 – 1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal Phospho-MKNK1-T197/202 antibody.
Check alternative names for the antibodyExpand
MAP kinase interacting kinase 1 antibody|MAP kinase interacting serine/threonine kinase 1 antibody|MAP kinase signal integrating kinase 1 antibody|MAP kinase signal-integrating kinase 1 antibody|MAP kinase-interacting serine/threonine-protein kinase 1 antibody|MAPK signal integrating kinase 1 antibody|MITOGEN-ACTIVATED PROTEIN KINASE-INTERACTING SERINE/THREONINE KINASE 1 antibody|mknk1 antibody|MKNK1_HUMAN antibody|MNK 1 antibody|Mnk1 antibody|Anti-MNK1 antibody (ab89223)
SCBT cat No: sc-133107|sc-6965|sc-133108|sc-133246|sc-28780|sc-6962|sc-271559|
Rabbit polyclonal Phospho-MKNK1-T197/202 antibody
|Catalogue No.|| |
A phospho specific peptide corresponding to residues surrounding T197/202 of human MKNK1
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 51kDa/Observed: Refer to figures
Phospho-MKNK1-T197/202 antibody was tube-contained.
Phospho-MKNK1-T197/202 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.
|Protein tissue specificity|| |
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.; Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Dual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase. MAPK3/ERK1 is one of the kinases which activate MKNK1/MNK1. Phosphorylation by PAK2 leads to a reduced phosphorylation of EIF4G1.
|Protein cellular localization|| |
Isoform 2: Cytoplasm.; Isoform 3: Cytoplasm. Nucleus.
This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene.
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|Product type|| |
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