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Rabbit Polyclonal Phospho-Neuro D (S274) antibody (STJ90633)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for Neuro D (phospho Ser274) Polyclonal Antibody.
Check alternative names for the antibodyExpand
NEUROD1 antibody, BHLHA3 antibody, NEUROD antibody,|atonal antibody|basic helix loop helix transcription factor antibody|BETA 2 antibody|Beta cell E box transactivator 2 antibody|BETA2 antibody|BHF 1 antibody|BHF1 antibody|bHLHa3 antibody|class A basic helix loop helix protein 3 antibody|Class A basic helix-loop-helix protein 3 antibody|MODY 6 antibody|MODY6 antibody|NDF1_HUMAN antibody|NeuroD antibody|NeuroD1 antibody|Neurogenic differentiation 1 antibody|Neurogenic differentiation factor 1 antibody|neurogenic helix loop helix protein NEUROD antibody|Neuronal differentiation 1 antibody|Anti-NeuroD1 antibody (ab60704)
SCBT cat No: sc-46684|sc-398891|sc-1086|sc-20805|sc-1084|
Neuro D (phospho Ser274) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-Neuro D (S274) Polyclonal Antibody detects endogenous levels of Neuro D protein only when phosphorylated at S274.
Synthesized phospho-peptide derived from Neuro D (phospho Ser274) at AA range 210-290
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:5000;
|Molecular weight|| |
Neuro D (phospho Ser274) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Neuro D (phospho Ser274) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Neurogenic differentiation factor 1 antibody, NeuroD antibody, NeuroD1 antibody, Class A basic helix-loop-helix protein 3 antibody, bHLHa3 antibody
|Protein names|| |
Neurogenic differentiation factor 1 , NeuroD , NeuroD1 , Class A basic helix-loop-helix protein 3 , bHLHa3
|Protein function|| |
Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5′-CANNTG-3′. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).
|Involvement in disease|| |
Maturity-onset diabetes of the young 6 (MODY6) [MIM:606394]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body’s own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Contains 1 bHLH (basic helix-loop-helix) domain.
|Protein post-translational modifications|| |
Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth. Phosphorylated by MAPK1; phosphorylation regulates heterodimerization and DNA-binding activities. Phosphorylation on Ser-266 and Ser-274 increases transactivation on the insulin promoter in glucose-stimulated insulinoma cells (By similarity).
|Protein cellular localization|| |
Cytoplasm / Nucleus
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St John’s Laboratory Ltd.
|Product type|| |
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