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Rabbit Polyclonal Phospho-NF2 (S518) antibody (STJ90340)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for NF2 (phospho Ser518) Polyclonal Antibody.
Check alternative names for the antibodyExpand
NF2 antibody, SCH antibody,|ACN antibody|BANF antibody|Bilateral acoustic neuroma antibody|MERL_HUMAN antibody|Merlin antibody|Moesin ezrin radixin like protein antibody|Moesin ezrin radizin like antibody|Moesin-ezrin-radixin-like protein antibody|Neurofibromatosis 2 antibody|Neurofibromatosis type 2 antibody|Neurofibromatosis2 antibody|Neurofibromin 2 antibody|Neurofibromin-2 antibody|Neurofibromin2 antibody|NF 2 antibody|Nf2 antibody|SCH antibody|Schwannomerlin antibody|Schwannomin antibody|Anti-NF2 / Merlin antibody [AF1G4] (ab88957)
SCBT cat No: sc-331|sc-55575|sc-332|sc-55574|sc-28247|sc-271718|
NF2 (phospho Ser518) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-NF2 (S518) Polyclonal Antibody detects endogenous levels of NF2 protein only when phosphorylated at S518.
Synthesized phospho-peptide derived from NF2 (phospho Ser518) at AA range 460-540
WB, IHC, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000;
|Molecular weight|| |
NF2 (phospho Ser518) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
NF2 (phospho Ser518) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Merlin antibody, Moesin-ezrin-radixin-like protein antibody, Neurofibromin-2 antibody, Schwannomerlin antibody, Schwannomin antibody
|Protein names|| |
Merlin , Moesin-ezrin-radixin-like protein , Neurofibromin-2 , Schwannomerlin , Schwannomin
|Protein function|| |
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.
|Protein tissue specificity|| |
Widely expressed. Isoform 1 and isoform 3 are predominant. Isoform 4, isoform 5 and isoform 6 are expressed moderately. Isoform 8 is found at low frequency. Isoform 7, isoform 9 and isoform 10 are not expressed in adult tissues, with the exception of adult retina expressing isoform 10. Isoform 9 is faintly expressed in fetal brain, heart, lung, skeletal muscle and spleen. Fetal thymus expresses isoforms 1, 7, 9 and 10 at similar levels.
|Involvement in disease|| |
Neurofibromatosis 2 (NF2) [MIM:101000]: Genetic disorder characterized by bilateral vestibular schwannomas (formerly called acoustic neuromas), schwannomas of other cranial and peripheral nerves, meningiomas, and ependymomas. It is inherited in an autosomal dominant fashion with full penetrance. Affected individuals generally develop symptoms of eighth-nerve dysfunction in early adulthood, including deafness and balance disorder. Although the tumors of NF2 are histologically benign, their anatomic location makes management difficult, and patients suffer great morbidity and mortality. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Schwannomatosis 1 (SWNTS1) [MIM:162091]: A cancer syndrome in which patients develop multiple non-vestibular schwannomas, benign neoplasms that arise from Schwann cells of the cranial, peripheral, and autonomic nerves. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Mesothelioma, malignant (MESOM) [MIM:156240]: An aggressive neoplasm of the serosal lining of the chest. It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. . Note: The disease may be caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Contains 1 FERM domain.
|Protein post-translational modifications|| |
Phosphorylation of Ser-518 inhibits nuclear localization by disrupting the intramolecular association of the FERM domain with the C-terminal tail. / Ubiquitinated by the CUL4A-RBX1-DDB1-DCAF1/VprBP E3 ubiquitin-protein ligase complex for ubiquitination and subsequent proteasome-dependent degradation.
|Protein cellular localization|| |
Cell projection > filopodium membrane; Peripheral membrane protein; Cytoplasmic side / Cell projection > ruffle membrane; Peripheral membrane protein; Cytoplasmic side / Nucleus / Cytoplasm > perinuclear region / Cytoplasmic granule / Cytoplasm > perinuclear region / Cytoplasmic granule / Nucleus / Cell projection > filopodium membrane; Peripheral membrane protein; Cytoplasmic side / Cell projection > ruffle membrane; Peripheral membrane protein; Cytoplasmic side / Cytoplasm > perinuclear region / Cytoplasmic granule / Cytoplasm > cytoskeleton
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St John’s Laboratory Ltd.
|Product type|| |
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