Rabbit Polyclonal Phospho-NFATc4 (S676) antibody (STJ90473)

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Reactivity: Human, Mouse
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-NFATc4 (S676) antibody (STJ90473)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for NFATc4 (phospho Ser676) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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NFATC4 antibody, NFAT3 antibody,|cytoplasmic 4 antibody|NF ATc4 antibody|NF-AT3 antibody|NF-ATc4 antibody|NFAC4_HUMAN antibody|NFAT3 antibody|NFATc4 antibody|Nuclear factor of activated T cells cytoplasmic 4 antibody|Nuclear factor of activated T cells cytoplasmic calcineurin dependent 4 antibody|Nuclear factor of activated T-cells antibody|T cell transcription factor NFAT3 antibody|T-cell transcription factor NFAT3 antibody|Anti-NFATC4 antibody (ab62613)
SCBT cat No: sc-32989|

 

Name

NFATc4 (phospho Ser676) Polyclonal Antibody

Catalogue No.

STJ90473

Reactivity

Human, Mouse

Specificity

Phospho-NFATc4 (S676) Polyclonal Antibody detects endogenous levels of NFATc4 protein only when phosphorylated at S676.

Immunogen

Synthesized phospho-peptide derived from NFATc4 (phospho Ser676) at AA range 620-700

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

120 kDa

Formulation

NFATc4 (phospho Ser676) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

NFATc4 (phospho Ser676) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Nuclear factor of activated T-cells, cytoplasmic 4 antibody, NF-ATc4 antibody, NFATc4 antibody, T-cell transcription factor NFAT3 antibody, NF-AT3 antibody

Database links

Human UniProt/Swiss-Prot:Q14934;Mouse UniPort/Swiss-Prot: Q8K120;Rat UniProt/Swiss-Port: D3Z9H7;Human Entrez Gene: 4776;Mouse Entrez Gene: 73181;Rat Entrez Gene: Rn.23727

Protein names

Nuclear factor of activated T-cells, cytoplasmic 4 , NF-ATc4 , NFATc4 , T-cell transcription factor NFAT3 , NF-AT3

Protein function

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons.

Protein tissue specificity

Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. Detected in hippocampus.

Protein sequence and domain

Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors. / Contains 1 IPT/TIG domain. / Contains 1 RHD (Rel-like) domain.

Protein post-translational modifications

Phosphorylated by NFATC-kinases; dephosphorylated by calcineurin. Phosphorylated on Ser-168 and Ser-170 by MTOR, IRAK1, MAPK7 and MAPK14, on Ser-213 and Ser-217 by MAPK8 and MAPK9, and on Ser-289 and Ser-344 by RPS6KA3. Phosphorylated by GSK3B. / Ubiquitinated, leading to its degradation by the proteasome and reduced transcriptional activity. Ubiquitination and reduction in transcriptional activity can be further facilitated through GSK3B-dependent phosphorylation. Polyubiquitin linkage is mainly through ‘Lys-48’.

Protein cellular localization

Cytoplasm / Nucleus

Research area

All research areas>Transcription Regulators>NFAT
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize NFATc4 (phospho Ser676) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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