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Rabbit Polyclonal Phospho-NFATc4 (S676) antibody (STJ90473)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for NFATc4 (phospho Ser676) Polyclonal Antibody.
Check alternative names for the antibodyExpand
NFATC4 antibody, NFAT3 antibody,|cytoplasmic 4 antibody|NF ATc4 antibody|NF-AT3 antibody|NF-ATc4 antibody|NFAC4_HUMAN antibody|NFAT3 antibody|NFATc4 antibody|Nuclear factor of activated T cells cytoplasmic 4 antibody|Nuclear factor of activated T cells cytoplasmic calcineurin dependent 4 antibody|Nuclear factor of activated T-cells antibody|T cell transcription factor NFAT3 antibody|T-cell transcription factor NFAT3 antibody|Anti-NFATC4 antibody (ab62613)
SCBT cat No: sc-32989|
NFATc4 (phospho Ser676) Polyclonal Antibody
|Catalogue No.|| |
Phospho-NFATc4 (S676) Polyclonal Antibody detects endogenous levels of NFATc4 protein only when phosphorylated at S676.
Synthesized phospho-peptide derived from NFATc4 (phospho Ser676) at AA range 620-700
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
|Molecular weight|| |
NFATc4 (phospho Ser676) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
NFATc4 (phospho Ser676) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Nuclear factor of activated T-cells, cytoplasmic 4 antibody, NF-ATc4 antibody, NFATc4 antibody, T-cell transcription factor NFAT3 antibody, NF-AT3 antibody
|Protein names|| |
Nuclear factor of activated T-cells, cytoplasmic 4 , NF-ATc4 , NFATc4 , T-cell transcription factor NFAT3 , NF-AT3
|Protein function|| |
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons.
|Protein tissue specificity|| |
Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. Detected in hippocampus.
|Protein sequence and domain|| |
Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors. / Contains 1 IPT/TIG domain. / Contains 1 RHD (Rel-like) domain.
|Protein post-translational modifications|| |
Phosphorylated by NFATC-kinases; dephosphorylated by calcineurin. Phosphorylated on Ser-168 and Ser-170 by MTOR, IRAK1, MAPK7 and MAPK14, on Ser-213 and Ser-217 by MAPK8 and MAPK9, and on Ser-289 and Ser-344 by RPS6KA3. Phosphorylated by GSK3B. / Ubiquitinated, leading to its degradation by the proteasome and reduced transcriptional activity. Ubiquitination and reduction in transcriptional activity can be further facilitated through GSK3B-dependent phosphorylation. Polyubiquitin linkage is mainly through ‘Lys-48’.
|Protein cellular localization|| |
Cytoplasm / Nucleus
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St John’s Laboratory Ltd.
|Product type|| |
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