Rabbit Polyclonal Phospho-NFKBIB-S23 antibody (AP0262)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-NFKBIB-S23 antibody (AP0262)

Supplier: ABclonal Inc.

Recommended applications: IHC

Recommended dilution:

IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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IKBB antibody; TRIP9 antibody;
I kappa B beta antibody|I-kappa-B-beta antibody|IkappaBbeta antibody|IKB beta antibody|IkB-B antibody|IkB-beta antibody|IKBB antibody|IKBB_HUMAN antibody|IkBbeta antibody|NF kappa BIB antibody|NF-kappa-B inhibitor beta antibody|NF-kappa-BIB antibody|Nfkbib antibody|Thyroid receptor interacting protein 9 antibody|Thyroid receptor-interacting protein 9 antibody|TR interacting protein 9 antibody|TR-interacting protein 9 antibody|TRIP-9 antibody|TRIP9 antibody|Anti-IKB beta antibody (ab7547)

SCBT cat No: sc-74453|

Name

Rabbit Polyclonal Phospho-NFKBIB-S23 antibody

Catalogue No.

AP0262

Reactivity

Human, Mouse, Rat

Immunogen

A phospho specific peptide corresponding to residues surrounding S23 of human NFKBIB

Host

Rabbit

Applications

IHC

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

48kDa

Formulation

Phospho-NFKBIB-S23 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

IKBB antibody; TRIP9 antibody;

Protein names

IKBB; TRIP9;

Protein function

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

Protein tissue specificity

Expressed in all tissues examined.

Protein sequence and domain

Belongs to the NF-kappa-B inhibitor family.; Contains 6 ANK repeats.

Protein post-translational modifications

Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.

Protein cellular localization

Cytoplasm . Nucleus .

Background

The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Transcription-Regulators/">Transcription Regulators</a>><a href="http://antibodyplus.com/product-tag/I-B/">I κ B</a><br><a href="http://antibodyplus.com/product-tag/Transcription-Regulators/"&gt; (View all antibody categories related to Transcription Regulators)</a>

Note

AntibodyPlus can customize Phospho-NFKBIB-S23 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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