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Rabbit Polyclonal Phospho-Nibrin (S343) antibody (STJ90354)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for Nibrin (phospho Ser343) Polyclonal Antibody.
Check alternative names for the antibodyExpand
NBN antibody, NBS antibody, NBS1 antibody, P95 antibody,|AT V1 antibody|AT V2 antibody|ATV antibody|Cell cycle regulatory protein p95 antibody|FLJ10155 antibody|MGC87362 antibody|Nbn antibody|NBN_HUMAN antibody|NBS 1 antibody|NBS antibody|NBS1 antibody|Nibrin antibody|Nijmegen breakage syndrome 1 (nibrin) antibody|Nijmegen breakage syndrome antibody|Nijmegen breakage syndrome protein 1 antibody|p95 antibody|p95 protein of the MRE11/RAD50 complex antibody|Anti-p95 NBS1 antibody [Y112] – ChIP Grade (ab32074)
SCBT cat No: sc-56166|sc-374168|sc-515069|sc-8580|sc-11431|sc-8579|sc-65148|sc-136003|
Nibrin (phospho Ser343) Polyclonal Antibody
|Catalogue No.|| |
Phospho-Nibrin (S343) Polyclonal Antibody detects endogenous levels of Nibrin protein only when phosphorylated at S343.
Synthesized phospho-peptide derived from Nibrin (phospho Ser343) at AA range 280-360
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:5000;
|Molecular weight|| |
Nibrin (phospho Ser343) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Nibrin (phospho Ser343) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Nibrin antibody, Cell cycle regulatory protein p95 antibody, Nijmegen breakage syndrome protein 1 antibody
|Protein names|| |
Nibrin , Cell cycle regulatory protein p95 , Nijmegen breakage syndrome protein 1
|Protein function|| |
Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3′-5′ exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3′ overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
|Protein tissue specificity|| |
Ubiquitous. Expressed at high levels in testis.
|Involvement in disease|| |
Nijmegen breakage syndrome (NBS) [MIM:251260]: A disorder characterized by chromosomal instability, radiation sensitivity, microcephaly, growth retardation, immunodeficiency and predisposition to cancer, particularly to lymphoid malignancies. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Breast cancer (BC) [MIM:114480]: A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.; Aplastic anemia (AA) [MIM:609135]: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. It is characterized by peripheral pancytopenia and marrow hypoplasia. . Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry.; Note: Defects in NBN might play a role in the pathogenesis of childhood acute lymphoblastic leukemia (ALL). .
|Protein sequence and domain|| |
The FHA and BRCT domains are likely to have a crucial role for both binding to histone H2AFX and for relocalization of MRE11/RAD50 complex to the vicinity of DNA damage. / The C-terminal domain contains a MRE11-binding site, and this interaction is required for the nuclear localization of the MRN complex. / The EEXXXDDL motif at the C-terminus is required for the interaction with ATM and its recruitment to sites of DNA damage and promote the phosphorylation of ATM substrates, leading to the events of DNA damage response. / Contains 1 BRCT domain. / Contains 1 FHA domain.
|Protein post-translational modifications|| |
Phosphorylated by ATM in response of ionizing radiation, and such phosphorylation is responsible intra-S phase checkpoint control and telomere maintenance.
|Protein cellular localization|| |
Nucleus / Nucleus > PML body / Chromosome > telomere
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St John’s Laboratory Ltd.
|Product type|| |
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