Rabbit Polyclonal Phospho-NIPA (S354) antibody (STJ90545)

$99.00$319.00

Reactivity: Human, Mouse, Rat, Monkey
Applications: WB, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-NIPA (S354) antibody (STJ90545)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:40000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for NIPA (phospho Ser354) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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ZC3HC1 antibody, NIPA antibody, HSPC216 antibody,|hNIPA antibody|NIPA_HUMAN antibody|Nuclear interacting partner of ALK antibody|Nuclear interacting partner of anaplastic lymphoma kinase antibody|Nuclear-interacting partner of ALK antibody|Nuclear-interacting partner of anaplastic lymphoma kinase antibody|zc3hc1 antibody|Zinc finger C3HC type containing 1 antibody|Zinc finger C3HC-type protein 1 antibody|Phospho anti-NIPA (S354) antibody (ab63557)
SCBT cat No: sc-514368|sc-365058|

 

Name

NIPA (phospho Ser354) Polyclonal Antibody

Catalogue No.

STJ90545

Reactivity

Human, Mouse, Rat, Monkey

Specificity

Phospho-NIPA (S354) Polyclonal Antibody detects endogenous levels of NIPA protein only when phosphorylated at S354.

Immunogen

Synthesized phospho-peptide derived from NIPA (phospho Ser354) at AA range 290-370

Host

Rabbit

Applications

WB, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:40000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

55 kDa

Formulation

NIPA (phospho Ser354) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

NIPA (phospho Ser354) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Nuclear-interacting partner of ALK antibody, Nuclear-interacting partner of anaplastic lymphoma kinase antibody, hNIPA antibody, Zinc finger C3HC-type protein 1 antibody

Database links

Human UniProt/Swiss-Prot:Q86WB0;Mouse UniPort/Swiss-Prot: Q80YV2;Rat UniProt/Swiss-Port: B2RYM6;Human Entrez Gene: 51530;Mouse Entrez Gene: 232679;Rat Entrez Gene: Rn.56620

Protein names

Nuclear-interacting partner of ALK , Nuclear-interacting partner of anaplastic lymphoma kinase , hNIPA , Zinc finger C3HC-type protein 1

Protein function

Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. /

Protein tissue specificity

Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes.

Protein sequence and domain

The F-box-like region is required for the interaction with SKP1. / Contains 1 C3HC-type zinc finger.

Protein post-translational modifications

Phosphorylated. Phosphorylated on Ser residues at G2/M phase, but not during S and G0 phases. May also be weakly phosphorylated on Tyr residues. Ser-354 phosphorylation, a major site during the course of cell-cycle-dedendent phosphorylation, results in its dissociation from the SCF(NIPA) complex, thereby preventing CCNB1 degradation leading to mitotic entry.

Protein cellular localization

Nucleus

Research area

All research areas>Cell Cycle Proteins>NIPA
(View all antibody categories related to Cell Cycle Proteins)

Note

AntibodyPlus can customize NIPA (phospho Ser354) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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