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Rabbit Polyclonal Phospho-NIPA (S354) antibody (STJ90545)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:40000;
Recommended protocols: check protocols
Click or hover above images to see image description for NIPA (phospho Ser354) Polyclonal Antibody.
Check alternative names for the antibodyExpand
ZC3HC1 antibody, NIPA antibody, HSPC216 antibody,|hNIPA antibody|NIPA_HUMAN antibody|Nuclear interacting partner of ALK antibody|Nuclear interacting partner of anaplastic lymphoma kinase antibody|Nuclear-interacting partner of ALK antibody|Nuclear-interacting partner of anaplastic lymphoma kinase antibody|zc3hc1 antibody|Zinc finger C3HC type containing 1 antibody|Zinc finger C3HC-type protein 1 antibody|Phospho anti-NIPA (S354) antibody (ab63557)
SCBT cat No: sc-514368|sc-365058|
NIPA (phospho Ser354) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat, Monkey
Phospho-NIPA (S354) Polyclonal Antibody detects endogenous levels of NIPA protein only when phosphorylated at S354.
Synthesized phospho-peptide derived from NIPA (phospho Ser354) at AA range 290-370
WB, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:40000;
|Molecular weight|| |
NIPA (phospho Ser354) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
NIPA (phospho Ser354) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Nuclear-interacting partner of ALK antibody, Nuclear-interacting partner of anaplastic lymphoma kinase antibody, hNIPA antibody, Zinc finger C3HC-type protein 1 antibody
|Protein names|| |
Nuclear-interacting partner of ALK , Nuclear-interacting partner of anaplastic lymphoma kinase , hNIPA , Zinc finger C3HC-type protein 1
|Protein function|| |
Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. /
|Protein tissue specificity|| |
Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes.
|Protein sequence and domain|| |
The F-box-like region is required for the interaction with SKP1. / Contains 1 C3HC-type zinc finger.
|Protein post-translational modifications|| |
Phosphorylated. Phosphorylated on Ser residues at G2/M phase, but not during S and G0 phases. May also be weakly phosphorylated on Tyr residues. Ser-354 phosphorylation, a major site during the course of cell-cycle-dedendent phosphorylation, results in its dissociation from the SCF(NIPA) complex, thereby preventing CCNB1 degradation leading to mitotic entry.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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