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Rabbit Polyclonal Phospho-NOS3-S1177 antibody (AP0421)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:1000
IHC 1:50 – 1:100
IF 1:100 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit Polyclonal Phospho-NOS3-S1177 antibody.
Check alternative names for the antibodyExpand
eNOS antibody; ECNOS antibody;
cNOS antibody|Constitutive NOS antibody|EC NOS antibody|EC-NOS antibody|ecNOS antibody|Endothelial nitric oxidase synthase antibody|Endothelial nitric oxide synthase antibody|Endothelial nitric oxide synthase 3 antibody|Endothelial NOS antibody|eNOS antibody|Nitric oxide synthase 3 (endothelial cell) antibody|Nitric oxide synthase 3 antibody|Nitric oxide synthase 3 endothelial cell antibody|Nitric oxide synthase endothelial antibody|Nitric oxide synthase, endothelial antibody|NOS 3 antibody|NOS III antibody|NOS type III antibody|NOS3 antibody|NOS3_HUMAN antibody|NOSIII antibody|Anti-eNOS antibody [M221] (ab76198)
SCBT cat No: sc-376751|sc-136977|sc-654|sc-376542|sc-8311|sc-653|sc-137118|sc-46423|sc-365363|sc-137111|sc-67003|sc-137117|sc-373954|
Rabbit Polyclonal Phospho-NOS3-S1177 antibody
|Catalogue No.|| |
Human, Mouse, Rat
A phospho specific peptide corresponding to residues surrounding S1177 of human NOS3
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:1000<br/>IHC 1:50 – 1:100<br/>IF 1:100 – 1:200
|Molecular weight|| |
Phospho-NOS3-S1177 antibody was tube-contained.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
eNOS antibody; ECNOS antibody;
|Database links|| |
Human UniProt/Swiss-Prot:<a href="http://www.uniprot.org/uniprot/P29474">P29474</a>
|Protein names|| |
|Protein function|| |
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.; Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
|Protein tissue specificity|| |
Platelets, placenta, liver and kidney.
|Protein sequence and domain|| |
Belongs to the NOS family.; Contains 1 FAD-binding FR-type domain.; Contains 1 flavodoxin-like domain.
|Protein post-translational modifications|| |
Phosphorylation by AMPK at Ser-1177 in the presence of Ca(2+)-calmodulin (CaM) activates activity. In absence of Ca(2+)-calmodulin, AMPK also phosphorylates Thr-495, resulting in inhibition of activity (By similarity). Phosphorylation of Ser-114 by CDK5 reduces activity.
|Protein cellular localization|| |
Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene.
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Synthesis-and-Degradation/">Synthesis and Degradation</a>><a href="http://antibodyplus.com/product-tag/NOS3/">NOS3</a><br><a href="http://antibodyplus.com/product-tag/Synthesis-and-Degradation/"> (View all antibody categories related to Synthesis and Degradation)</a>
AntibodyPlus can customize Phospho-NOS3-S1177 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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