Rabbit Polyclonal Phospho-NTRK1-S791 antibody (AP0272)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal Phospho-NTRK1-S791 antibody (AP0272)

Supplier: ABclonal Inc.

Recommended applications: WB,IF

Recommended dilution:

WB 1:500 – 1:2000
IF 1:100 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

MTC antibody; TRK antibody; TRK1 antibody; TRKA antibody; Trk-A antibody; p140-TrkA antibody;
MTC antibody|Neurotrophic tyrosine kinase receptor type 1 antibody|Neurotrophin receptor tyrosine kinase type 2 antibody|NTRK1 antibody|NTRK2 antibody|TRK antibody|TRKA antibody|TRKB antibody|Tyrosine kinase receptor A antibody|Tyrosine kinase receptor B antibody|Anti-TRKA+B antibody [1.A.37] (ab18137)

SCBT cat No: sc-135645|sc-66159|sc-135790|sc-135789|sc-71947|sc-5839|sc-398471|

Name

Rabbit Polyclonal Phospho-NTRK1-S791 antibody

Catalogue No.

AP0272

Reactivity

Human, Mouse, Rat

Immunogen

A phospho specific peptide corresponding to residues surrounding S791 of human NTRK1

Host

Rabbit

Applications

WB, IF

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

140kDa

Formulation

Phospho-NTRK1-S791 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MTC antibody; TRK antibody; TRK1 antibody; TRKA antibody; Trk-A antibody; p140-TrkA antibody;

Protein names

MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA;

Protein function

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.; Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed.

Protein tissue specificity

Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors.

Protein sequence and domain

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.; Contains 2 Ig-like C2-type (immunoglobulin-like) domains.; Contains 2 LRR (leucine-rich) repeats.; Contains 1 LRRCT domain.; Contains 1 protein kinase domain. The transmembrane domain mediates interaction with KIDINS220.; The extracellular domain mediates interaction with NGFR.

Protein post-translational modifications

Ligand-mediated autophosphorylation. Interaction with SQSTM1 is phosphotyrosine-dependent. Autophosphorylation at Tyr-496 mediates interaction and phosphorylation of SHC1.; N-glycosylated (Probable). Isoform TrkA-I is N-glycosylated.; Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the internalization of the receptor (By similarity).

Protein cellular localization

Cell membrane ; Single-pass type I membrane protein . Early endosome membrane ; Single-pass type I membrane protein . Late endosome membrane ; Single-pass type I membrane protein . Note=Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes (By similarity).

Background

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Neurobiology/">Neurobiology</a>><a href="http://antibodyplus.com/product-tag/Trk/">Trk</a><br><a href="http://antibodyplus.com/product-tag/Neurobiology/"&gt; (View all antibody categories related to Neurobiology)</a>

Note

AntibodyPlus can customize Phospho-NTRK1-S791 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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