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Rabbit Polyclonal Phospho-p120 (Y228) antibody (STJ91079)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for p120 (phospho Tyr228) Polyclonal Antibody.
Check alternative names for the antibodyExpand
CTNND1 antibody, KIAA0384 antibody,|Cadherin associated Src substrate antibody|Cadherin-associated Src substrate antibody|CAS antibody|Catenin (cadherin associated protein) delta 1 antibody|Catenin delta 1 antibody|Catenin delta antibody|Catenin delta-1 antibody|CTND1_HUMAN antibody|CTNND 1 antibody|CTNND antibody|CTNND1 antibody|KIAA0384 antibody|p120 antibody|P120 CAS antibody|p120 catenin antibody|P120 CTN antibody|p120(cas) antibody|p120(ctn) antibody|P120CAS antibody|P120CTN antibody|Anti-delta 1 Catenin antibody [EPR357(2)] (ab92514)
SCBT cat No: sc-1101|
p120 (phospho Tyr228) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-p120 (Y228) Polyclonal Antibody detects endogenous levels of p120 protein only when phosphorylated at Y228.
Synthesized phospho-peptide derived from p120 (phospho Tyr228) at AA range 180-260
WB, IHC, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000;
|Molecular weight|| |
p120 (phospho Tyr228) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
p120 (phospho Tyr228) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Catenin delta-1 antibody, Cadherin-associated Src substrate antibody, CAS antibody, p120 catenin antibody, p120antibody, ctn antibody, antibody, p120antibody, cas antibody
|Protein names|| |
Catenin delta-1 , Cadherin-associated Src substrate , CAS , p120 catenin , p120, ctn , , p120, cas
|Protein function|| |
Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.
|Protein tissue specificity|| |
Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs.
|Protein sequence and domain|| |
A possible nuclear localization signal exists in all isoforms where Asp-626–631-Arg are deleted. / ARM repeats 1 to 5 mediate interaction with cadherins. / Belongs to the beta-catenin family. / Contains 10 ARM repeats.
|Protein post-translational modifications|| |
Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK7/PAK5. Dephosphorylated by PTPRJ.
|Protein cellular localization|| |
Cytoplasm / Nucleus / Cell membrane / Nucleus / Nucleus / Nucleus
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St John’s Laboratory Ltd.
|Product type|| |
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