Rabbit Polyclonal Phospho-p120 (Y228) antibody (STJ91079)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, IHC, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-p120 (Y228) antibody (STJ91079)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for p120 (phospho Tyr228) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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CTNND1 antibody, KIAA0384 antibody,|Cadherin associated Src substrate antibody|Cadherin-associated Src substrate antibody|CAS antibody|Catenin (cadherin associated protein) delta 1 antibody|Catenin delta 1 antibody|Catenin delta antibody|Catenin delta-1 antibody|CTND1_HUMAN antibody|CTNND 1 antibody|CTNND antibody|CTNND1 antibody|KIAA0384 antibody|p120 antibody|P120 CAS antibody|p120 catenin antibody|P120 CTN antibody|p120(cas) antibody|p120(ctn) antibody|P120CAS antibody|P120CTN antibody|Anti-delta 1 Catenin antibody [EPR357(2)] (ab92514)
SCBT cat No: sc-1101|

 

Name

p120 (phospho Tyr228) Polyclonal Antibody

Catalogue No.

STJ91079

Reactivity

Human, Mouse, Rat

Specificity

Phospho-p120 (Y228) Polyclonal Antibody detects endogenous levels of p120 protein only when phosphorylated at Y228.

Immunogen

Synthesized phospho-peptide derived from p120 (phospho Tyr228) at AA range 180-260

Host

Rabbit

Applications

WB, IHC, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

108 kDa

Formulation

p120 (phospho Tyr228) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

p120 (phospho Tyr228) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Catenin delta-1 antibody, Cadherin-associated Src substrate antibody, CAS antibody, p120 catenin antibody, p120antibody, ctn antibody, antibody, p120antibody, cas antibody

Database links

Human UniProt/Swiss-Prot:O60716;Mouse UniPort/Swiss-Prot: P30999;Rat UniProt/Swiss-Port: D3ZZZ9;Human Entrez Gene: 1500;Mouse Entrez Gene: 12388;Rat Entrez Gene: Rn.9435

Protein names

Catenin delta-1 , Cadherin-associated Src substrate , CAS , p120 catenin , p120, ctn , , p120, cas

Protein function

Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.

Protein tissue specificity

Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs.

Protein sequence and domain

A possible nuclear localization signal exists in all isoforms where Asp-626–631-Arg are deleted. / ARM repeats 1 to 5 mediate interaction with cadherins. / Belongs to the beta-catenin family. / Contains 10 ARM repeats.

Protein post-translational modifications

Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK7/PAK5. Dephosphorylated by PTPRJ.

Protein cellular localization

Cytoplasm / Nucleus / Cell membrane / Nucleus / Nucleus / Nucleus

Research area

All research areas>Cell Adhesion Proteins>p120
(View all antibody categories related to Cell Adhesion Proteins)

Note

AntibodyPlus can customize p120 (phospho Tyr228) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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