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Rabbit Polyclonal Phospho-p130 Cas (Y249) antibody (STJ90858)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for p130 Cas (phospho Tyr249) Polyclonal Antibody.
Check alternative names for the antibodyExpand
BCAR1 antibody, CAS antibody, CASS1 antibody, CRKAS antibody,|BCAR 1 antibody|Bcar1 antibody|BCAR1_HUMAN antibody|Breast cancer anti estrogen resistance 1 antibody|Breast cancer anti estrogen resistance 1 protein antibody|Breast cancer anti-estrogen resistance protein 1 antibody|CAS antibody|Cas scaffolding protein family member 1 antibody|CAS1 antibody|Cass1 antibody|Crk associated substrate antibody|Crk associated substrate p130Cas antibody|CRK-associated substrate antibody|CRKAS antibody|FLJ12176 antibody|FLJ45059 antibody|p130cas antibody|Anti-BCAR1 antibody [M144] (ab31831)
SCBT cat No: sc-20029|sc-71796|sc-515479|sc-860|sc-365200|sc-65517|sc-859|
p130 Cas (phospho Tyr249) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Phospho-p130 Cas (Y249) Polyclonal Antibody detects endogenous levels of p130 Cas protein only when phosphorylated at Y249.
Synthesized phospho-peptide derived from p130 Cas (phospho Tyr249) at AA range 190-270
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
|Molecular weight|| |
p130 Cas (phospho Tyr249) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
p130 Cas (phospho Tyr249) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Breast cancer anti-estrogen resistance protein 1 antibody, CRK-associated substrate antibody, Cas scaffolding protein family member 1 antibody, p130cas antibody
|Protein names|| |
Breast cancer anti-estrogen resistance protein 1 , CRK-associated substrate , Cas scaffolding protein family member 1 , p130cas
|Protein function|| |
Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.
|Protein tissue specificity|| |
Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line.
|Protein sequence and domain|| |
Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL1 SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with NEDD9 (By similarity). / A serine-rich region promotes activation of the serum response element (SRE). / The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of PTK2/FAK11. / Belongs to the CAS family. / Contains 1 SH3 domain.
|Protein post-translational modifications|| |
PTK2/FAK1 activation mediates phosphorylation at the YDYVHL motif; phosphorylation is most likely catalyzed by SRC family members. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin-mediated adhesion of cells to the extracellular matrix. / Dephosphorylated by PTPN14 at Tyr-128.
|Protein cellular localization|| |
Cell junction > focal adhesion / Cytoplasm
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St John’s Laboratory Ltd.
|Product type|| |
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