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Rabbit Polyclonal Phospho-p16 (S326) antibody (STJ90987)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for p16 (phospho Ser326) Polyclonal Antibody.
Check alternative names for the antibodyExpand
CDKN2A antibody, CDKN2 antibody, MTS1 antibody,|CCM2 antibody|CDK4 inhibitor p16 INK4 antibody|CDK4I antibody|CDKN2 antibody|CDKN2A antibody|Cell cycle negative regulator beta antibody|CMM2 antibody|Cyclin dependent kinase 4 inhibitor A antibody|Cyclin dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4) antibody|Cyclin Dependent Kinase Inhibitor 2A antibody|Cyclin dependent kinase inhibitor 2A isoform 4 antibody|Cyclin dependent kinase inhibitor 2A isoforms 1/2/3 antibody|Cyclin dependent kinase inhibitor p16 antibody|INK4 antibody|INK4A antibody|MLM antibody|MTS1 antibody|Multiple tumor suppressor 1 antibody|p14 antibody|p16 antibody|P16INK4 antibody|p16INK4a antibody|p19 antibody|p19Arf antibody|TP16 antibody|Anti-CDKN2A/p16INK4a antibody [EPR1473] (ab108349)
SCBT cat No: To be updated
p16 (phospho Ser326) Polyclonal Antibody
|Catalogue No.|| |
Phospho-p16 (S326) Polyclonal Antibody detects endogenous levels of p16 protein only when phosphorylated at S326.
Synthesized phospho-peptide derived from p16 (phospho Ser326) at AA range 90-170
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;
|Molecular weight|| |
p16 (phospho Ser326) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
p16 (phospho Ser326) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Cyclin-dependent kinase inhibitor 2A antibody, Cyclin-dependent kinase 4 inhibitor A antibody, CDK4I antibody, Multiple tumor suppressor 1 antibody, MTS-1 antibody, p16-INK4a antibody, p16-INK4 antibody, p16INK4A antibody
|Protein names|| |
Cyclin-dependent kinase inhibitor 2A , Cyclin-dependent kinase 4 inhibitor A , CDK4I , Multiple tumor suppressor 1 , MTS-1 , p16-INK4a , p16-INK4 , p16INK4A
|Protein function|| |
Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
|Protein tissue specificity|| |
Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific.
|Involvement in disease|| |
Note: The association between cutaneous and uveal melanomas in some families suggests that mutations in CDKN2A may account for a proportion of uveal melanomas. However, CDKN2A mutations are rarely found in uveal melanoma patients.; Melanoma, cutaneous malignant 2 (CMM2) [MIM:155601]: A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.; Familial atypical multiple mole melanoma-pancreatic carcinoma syndrome (FAMMMPC) [MIM:606719]: An inherited cancer predisposition syndrome characterized by an increased risk of developing malignant melanoma and/or pancreatic cancer. Mutation carriers within families may develop either or both types of cancer. Note: The disease is caused by mutations affecting the gene represented in this entry.; Melanoma-astrocytoma syndrome (MASTS) [MIM:155755]: Characterized by a dual predisposition to melanoma and neural system tumors, commonly astrocytoma. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. / Contains 4 ANK repeats.
|Protein post-translational modifications|| |
Phosphorylation seems to increase interaction with CDK4.
|Protein cellular localization|| |
Cytoplasm / Nucleus
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St John’s Laboratory Ltd.
|Product type|| |
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