Rabbit Polyclonal Phospho-p16 (S326) antibody (STJ90987)

$99.00$319.00

Reactivity: Human
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Phospho-p16 (S326) antibody (STJ90987)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for p16 (phospho Ser326) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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CDKN2A antibody, CDKN2 antibody, MTS1 antibody,|CCM2 antibody|CDK4 inhibitor p16 INK4 antibody|CDK4I antibody|CDKN2 antibody|CDKN2A antibody|Cell cycle negative regulator beta antibody|CMM2 antibody|Cyclin dependent kinase 4 inhibitor A antibody|Cyclin dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4) antibody|Cyclin Dependent Kinase Inhibitor 2A antibody|Cyclin dependent kinase inhibitor 2A isoform 4 antibody|Cyclin dependent kinase inhibitor 2A isoforms 1/2/3 antibody|Cyclin dependent kinase inhibitor p16 antibody|INK4 antibody|INK4A antibody|MLM antibody|MTS1 antibody|Multiple tumor suppressor 1 antibody|p14 antibody|p16 antibody|P16INK4 antibody|p16INK4a antibody|p19 antibody|p19Arf antibody|TP16 antibody|Anti-CDKN2A/p16INK4a antibody [EPR1473] (ab108349)
SCBT cat No: To be updated

 

Name

p16 (phospho Ser326) Polyclonal Antibody

Catalogue No.

STJ90987

Reactivity

Human

Specificity

Phospho-p16 (S326) Polyclonal Antibody detects endogenous levels of p16 protein only when phosphorylated at S326.

Immunogen

Synthesized phospho-peptide derived from p16 (phospho Ser326) at AA range 90-170

Host

Rabbit

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

20 kDa

Formulation

p16 (phospho Ser326) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

p16 (phospho Ser326) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Cyclin-dependent kinase inhibitor 2A antibody, Cyclin-dependent kinase 4 inhibitor A antibody, CDK4I antibody, Multiple tumor suppressor 1 antibody, MTS-1 antibody, p16-INK4a antibody, p16-INK4 antibody, p16INK4A antibody

Database links

Human UniProt/Swiss-Prot:P42771;Human Entrez Gene: 1029;

Protein names

Cyclin-dependent kinase inhibitor 2A , Cyclin-dependent kinase 4 inhibitor A , CDK4I , Multiple tumor suppressor 1 , MTS-1 , p16-INK4a , p16-INK4 , p16INK4A

Protein function

Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.

Protein tissue specificity

Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific.

Involvement in disease

Note: The association between cutaneous and uveal melanomas in some families suggests that mutations in CDKN2A may account for a proportion of uveal melanomas. However, CDKN2A mutations are rarely found in uveal melanoma patients.; Melanoma, cutaneous malignant 2 (CMM2) [MIM:155601]: A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.; Familial atypical multiple mole melanoma-pancreatic carcinoma syndrome (FAMMMPC) [MIM:606719]: An inherited cancer predisposition syndrome characterized by an increased risk of developing malignant melanoma and/or pancreatic cancer. Mutation carriers within families may develop either or both types of cancer. Note: The disease is caused by mutations affecting the gene represented in this entry.; Melanoma-astrocytoma syndrome (MASTS) [MIM:155755]: Characterized by a dual predisposition to melanoma and neural system tumors, commonly astrocytoma. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. / Contains 4 ANK repeats.

Protein post-translational modifications

Phosphorylation seems to increase interaction with CDK4.

Protein cellular localization

Cytoplasm / Nucleus

Research area

All research areas>Cell Cycle Proteins>p15
(View all antibody categories related to Cell Cycle Proteins)

Note

AntibodyPlus can customize p16 (phospho Ser326) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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